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    Glossary Spermine

    naturally occurring compound involved in cellular metabolism and DNA stabilization

    Spermine is a naturally occurring polyamine compound found in all eukaryotic cells. It plays a crucial role in cellular metabolism and is involved in stabilizing the structure of DNA, RNA, and various proteins. In the context of hair and alopecia, spermine has been studied for its potential effects on hair growth and follicle health.

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    Research 30 of 87

    1. Spermidine/spermine-<i>N</i><sup>1</sup>-acetyltransferase: a key metabolic regulator AJP Endocrinology and Metabolism · 2008 · 305 citations
    2. Genetically Altered Expression of Spermidine/Spermine N1-Acetyltransferase Affects Fat Metabolism in Mice via Acetyl-CoA Journal of Biological Chemistry · 2006 · 128 citations
    3. Activation of Polyamine Catabolism Profoundly Alters Tissue Polyamine Pools and Affects Hair Growth and Female Fertility in Transgenic Mice Overexpressing Spermidine/SpermineN 1-Acetyltransferase Journal of Biological Chemistry · 1997 · 124 citations
    4. Overexpression of spermidine/spermine N1-acetyltransferase under the control of mouse metallothionein I promoter in transgenic mice: evidence for a striking post-transcriptional regulation of transgene expression by a polyamine analogue Biochemical Journal · 1999 · 43 citations
    5. Overexpression of spermidine/spermine N1-acetyltransferase under the control of mouse metallothionein I promoter in transgenic mice: evidence for a striking post-transcriptional regulation of transgene expression by a polyamine analogue Biochemical Journal · 1999 · 13 citations
    6. Topical spermine and putrescine stimulated DNA synthesis in the hairless mouse epidermis British Journal of Dermatology · 1980 · 10 citations
    7. Expression and distribution patterns of spermine, spermidine, and putrescine in rat hair follicle Histochemistry and Cell Biology · 2017 · 2 citations
    8. Spermine Lipid Assembled Nanoparticles for siRNA Delivery and Androgenetic Alopecia Therapy ACS Applied Materials & Interfaces · 2026
    9. Targeted expression of spermidine/spermine N1-acetyltransferase increases susceptibility to chemically induced skin carcinogenesis Carcinogenesis · 2002 · 54 citations
    10. Relation of Skin Polyamines to the Hairless Phenotype in Transgenic Mice Overexpressing Spermidine/Spermine N1-Acetyltransferase Journal of Investigative Dermatology · 2001 · 54 citations
    11. Disturbed Keratinocyte Differentiation in Transgenic Mice and Organotypic Keratinocyte Cultures as a Result of Spermidine/Spermine N1-Acetyltransferase Overexpression Journal of Investigative Dermatology · 2005 · 37 citations
    12. Activated Polyamine Catabolism Depletes Acetyl-CoA Pools and Suppresses Prostate Tumor Growth in TRAMP Mice Journal of Biological Chemistry · 2004 · 91 citations
    13. Inhibition of Polyamine Synthesis Alters Hair Follicle Function and Fiber Composition Journal of Investigative Dermatology · 1996 · 42 citations
    14. Polyamines and hair: a couple in search of perfection Experimental Dermatology · 2010 · 30 citations
    15. Synthetic studies toward the development of novel minoxidil analogs and conjugates with polyamines Tetrahedron Letters · 2010 · 12 citations
    16. Increased hair polyamine levels in patients with alzheimer's disease Annals of neurology · 2001 · 10 citations
    17. Synthesis of minoxidil conjugates and their evaluation as HL-60 differentiation agents Bioorganic & Medicinal Chemistry Letters · 2016 · 6 citations
    18. The RATIOnal Role of Polyamines in Epidermal Differentiation Journal of Investigative Dermatology · 2021
    19. Regulation of Hematopoietic Cell Development and Hair Growth in Mouse Models: Expression Analysis of Tudor-SN and Polyamine-Regulated Proteins Tampere University Institutional Repository (Tampere University) · 2013
    20. Comparative Studies on Polyamine Levels in Plasma and Urine of Androgenic Alopecia Patients Treated with Finasteride for a Period of Three Years International Journal of Applied Biology and P · 2020
    21. Cutaneous application of α-methylspermidine activates the growth of resting hair follicles in mice Amino Acids · 2009 · 12 citations
    22. A spermidine-based nutritional supplement prolongs the anagen phase of hair follicles in humans: a randomized, placebo-controlled, double-blind study Dermatology practical & conceptual · 2017 · 8 citations
    23. Surface modification and endothelialization of biomaterials as potential scaffolds for vascular tissue engineering applications Chemical Society Reviews · 2015 · 421 citations
    24. Genetically-manipulated adult stem cells as therapeutic agents and gene delivery vehicle for wound repair and regeneration Journal of Controlled Release · 2011 · 36 citations
    25. Characteristics of flutamide action on prostatic and testicular functions in the rat Journal of Steroid Biochemistry · 1988 · 30 citations
    26. Cicatricial Alopecia Research Foundation meeting, May 2016: Progress towards the diagnosis, treatment and cure of primary cicatricial alopecias Experimental Dermatology · 2018 · 22 citations
    27. Primary Cicatricial Alopecias Dermatologic Clinics · 2012 · 18 citations
    28. Chapter 14 Principles of drug metabolism Principles of Medical Biology · 1997 · 2 citations
    29. Metabolomic analysis of SMP30/GNL knockout mice treated with fermented vegetable and fruit extract (OM-X®) 2020 · 1 citations
    30. Primary cicatricial alopecias Expert Review of Dermatology · 2010 · 1 citations