Synthetic Studies Toward the Development of Novel Minoxidil Analogs and Conjugates with Polyamines

    February 2010 in “ Tetrahedron Letters ”
    George E. Magoulas, Stavros E. Bariamis, Constantinos M. Athanassopoulos, Dionissios Papaioannou
    Image of study
    TLDR New minoxidil compounds with better water solubility were made, but their full effects and safety need more research.
    The document from April 1, 2010, detailed the creation of novel polyamine-modified minoxidil analogs (PMMs) and minoxidil-polyamine conjugates (MPCs) to enhance the properties of minoxidil (MNX), a drug used for treating hypertension and male pattern baldness. The study involved attaching polyamines like putrescine, spermidine, and spermine to MNX using different synthetic methods. PMMs were produced through amination, N-oxidation, piperidine addition, and N-deprotection, while MPCs were synthesized via CDI-mediated activation of MNX and coupling with protected polyamines. These new compounds showed significantly better water solubility than MNX. However, the biological effects and detailed structure-activity relationship studies were still underway at the time of publication, and there was a note of caution regarding the potential increased toxicity due to the incorporation of polyamines, particularly spermine.
    Discuss this study in the Community →

    Research cited in this study

    7 / 7 results

    Related Community Posts Join

    6 / 1000+ results

      community Switching from Topical to Oral Minoxidil.

      in Minoxidil  279 upvotes 1 day ago
      Switching from topical to oral minoxidil for hair loss, with plans to use it alongside dutasteride. Users report mixed experiences, including increased body hair, potential heart-related side effects, and varying hair regrowth.

      community Oral Minoxidil- Be Careful!!!!!

      in Minoxidil  399 upvotes 2 days ago
      Oral minoxidil can cause severe side effects, including heart issues, even at low doses. Users suggest starting with a lower dose or using topical treatments to minimize risks.

      community How you guys use minoxidil? Need advice.

      in Minoxidil  5 upvotes 5 days ago
      A 23-year-old with Norwood 4 hair loss is using minoxidil, finasteride, oral minoxidil, a multivitamin, and derma rolling, seeking advice on whether to increase minoxidil usage despite cost concerns. A dermatologist recommended the regimen, and the user added derma rolling and tretinoin.

      community Minoxidil with Tretinoin together

      in Minoxidil  8 upvotes 1 week ago
      Combining tretinoin with minoxidil may improve absorption by exfoliating the scalp, but results vary. Users suggest starting with low frequency to avoid irritation, and some recommend additional treatments like finasteride or microneedling.

      community Genuine Minoxidil Sanity Check-Tiktok Shops

      in Minoxidil  187 upvotes 1 week ago
      A user bought Kirkland Minoxidil from a TikTok shop and sought confirmation of its authenticity through a bleach test, which some users warned could be dangerous. Many participants advised against buying from TikTok due to the risk of fakes, suggesting alternatives like buying from Costco or reputable online pharmacies.

    Similar Research

    5 / 1000+ results

      research The Fate of Trichohyalin

      135 citations, October 1997 in “Journal of biological chemistry/˜The œJournal of biological chemistry”
      Trichohyalin is modified by enzymes to form strong structures in hair cells.
      Proceedings of the Ninth World Congress for Hair Research 2015

      research Proceedings of the Ninth World Congress for Hair Research 2015

      January 2017 in “Journal of Investigative Dermatology Symposium Proceedings”
      The 2015 Hair Research Congress concluded that stem cells, maraviroc, and simvastatin could potentially treat Alopecia Areata, topical minoxidil, finasteride, and steroids could treat Frontal Fibrosing Alopecia, and PTGDR2 antagonists could also treat alopecia. They also found that low-level light therapy could help with hair loss, a robotic device could assist in hair extraction, and nutrition could aid hair growth. They suggested that Alopecia Areata is an inflammatory disorder, not a single disease, indicating a need for personalized treatments.