Synthetic Studies Toward the Development of Novel Minoxidil Analogs and Conjugates with Polyamines

    February 2010 in “ Tetrahedron Letters ”
    George E. Magoulas, Stavros E. Bariamis, Constantinos M. Athanassopoulos, Dionissios Papaioannou
    Image of study
    TLDR New minoxidil compounds with better water solubility were made, but their full effects and safety need more research.
    The document from April 1, 2010, detailed the creation of novel polyamine-modified minoxidil analogs (PMMs) and minoxidil-polyamine conjugates (MPCs) to enhance the properties of minoxidil (MNX), a drug used for treating hypertension and male pattern baldness. The study involved attaching polyamines like putrescine, spermidine, and spermine to MNX using different synthetic methods. PMMs were produced through amination, N-oxidation, piperidine addition, and N-deprotection, while MPCs were synthesized via CDI-mediated activation of MNX and coupling with protected polyamines. These new compounds showed significantly better water solubility than MNX. However, the biological effects and detailed structure-activity relationship studies were still underway at the time of publication, and there was a note of caution regarding the potential increased toxicity due to the incorporation of polyamines, particularly spermine.
    Discuss this study in the Community →

    Research cited in this study

    7 / 7 results

    Related Community Posts Join

    6 / 1000+ results

      community Should I add oral minoxidil right now?

      in Minoxidil  85 upvotes 5 days ago
      The user is considering adding oral minoxidil to their current hair loss treatment, which includes dutasteride and occasional finasteride, due to concerns about hair thinning and potential shedding. They are unsure if starting both treatments simultaneously could worsen shedding or if oral minoxidil might be beneficial.

      community Stoped minoxidil 5 weeks ago and still bloated

      in Minoxidil  103 upvotes 1 week ago
      The user stopped using minoxidil 5 weeks ago due to facial swelling, which initially subsided but then returned. Despite a healthy lifestyle and normal test results, the user is concerned about the persistent bloating.

      community Duoxidil / Dutasteride/ Minoxidil

      in Minoxidil  82 upvotes 1 week ago
      The conversation discusses a user's positive experience with hair loss treatments, including Duoxidil, oral Dutasteride, oral Minoxidil, and biotin, noting no side effects and effective results. The user plans to start a new cycle of Dutasteride and PRP sessions.

    Similar Research

    5 / 1000+ results

      research The Fate of Trichohyalin

      135 citations, October 1997 in “Journal of biological chemistry/˜The œJournal of biological chemistry”
      Trichohyalin is modified by enzymes to form strong structures in hair cells.
      Proceedings of the Ninth World Congress for Hair Research 2015

      research Proceedings of the Ninth World Congress for Hair Research 2015

      January 2017 in “Journal of Investigative Dermatology Symposium Proceedings”
      The 2015 Hair Research Congress concluded that stem cells, maraviroc, and simvastatin could potentially treat Alopecia Areata, topical minoxidil, finasteride, and steroids could treat Frontal Fibrosing Alopecia, and PTGDR2 antagonists could also treat alopecia. They also found that low-level light therapy could help with hair loss, a robotic device could assist in hair extraction, and nutrition could aid hair growth. They suggested that Alopecia Areata is an inflammatory disorder, not a single disease, indicating a need for personalized treatments.