Synthesis and Characterization of Inclusion Complex of the Vasodilator Drug Minoxidil with β-Cyclodextrin

April 2008 in “ Journal of Inclusion Phenomena and Macrocyclic Chemistry ”

Adriana Calderini, Francisco B. T. Pessine

minoxidil β-cyclodextrin inclusion complex vasodilator solubility wettability biodisponibility Rogaine

TLDR Minoxidil mixed with β-cyclodextrin improves solubility and gradual release.

The study synthesized and characterized an inclusion complex of minoxidil with β-cyclodextrin. The results showed the formation of a 1:1 complex between the two components, with a weak interaction in solution. The encapsulation of minoxidil with β-cyclodextrin is believed to increase its solubility and wettability, leading to a supported and gradual release of the drug and maximizing its biodisponibility over time.

View this study on link.springer.com →

Discuss this study in the Community →

Research cited in this study

1 / 1 results

research Minoxidil-Containing Dosage Forms: Skin Retention and After-Rinsing Hair-Growth Promotion

24 citations, January 2003 in “Drug Delivery”

Minoxidil-containing vesicles improve hair growth.

Related Community Posts Join

6 / 1000+ results

community how it feels to talk to tiktok kids about hairloss that isn’t shitty rosemary oil bloodflow and microneedling

in Satire 992 upvotes 1 month ago

Minoxidil and finasteride are effective for hair loss, especially when used together. Microneedling may enhance minoxidil's effects, but its standalone effectiveness is uncertain.

community JW Pharmaceutical shows superiority of 'JW0061' in hair growth over existing treatments in US

in Research/Science 99 upvotes 6 months ago

JW0061 shows superior hair growth results compared to existing treatments, with significant increases in hair follicles. The Wnt/β-catenin pathway is crucial for hair growth, and JW0061 activates this pathway effectively.

community New study shows that microneedling is an ineffective hair loss treatment

in Research/Science 1 year ago

The effectiveness of microneedling as a hair loss treatment, with evidence from studies and anecdotal accounts from other users. It is suggested that combining microneedling with minoxidil or finasteride may be more effective than using microneedling alone, although some people have had success using only microneedling.

community Why do I see so many people here recommend microneedling?

in Microneedling 108 upvotes 1 year ago

The efficacy of microneedling for hair regrowth as either a stand-alone therapy or adjunct to Minoxidil, and whether Tretinoin is a safer and more effective option. Replies include personal accounts from users who have had success with microneedling in combination with minoxidil and peptide serums, as well as considerations of technique, depth, and potential scarring.

community Finasteride and Dutasteride results compilation thread

in Finasteride/Dutasteride 82 upvotes 3 weeks ago

Combining finasteride and dutasteride may enhance hair regrowth by targeting different enzymes, with positive results reported. Minoxidil, both oral and topical, is also used to improve effectiveness.

community New drug for hair loss announced by Amplifica

in Research/Science 161 upvotes 1 year ago

Amplifica starting clinical trials for new hair loss drug. SCUBE3 protein discovered, stimulates hair growth, could be alternative to Minoxidil and Finasteride.

Related Research

1 / 1 results

research Synthesis and Characterization of Inclusion Complex of the Vasodilator Drug Minoxidil with β-Cyclodextrin

28 citations, April 2008 in “Journal of Inclusion Phenomena and Macrocyclic Chemistry”

Minoxidil mixed with β-cyclodextrin improves solubility and gradual release.