Synthesis and Characterization of Inclusion Complex of the Vasodilator Drug Minoxidil with β-Cyclodextrin
April 2008
in “
Journal of Inclusion Phenomena and Macrocyclic Chemistry
”
TLDR Minoxidil mixed with β-cyclodextrin improves solubility and gradual release.
The study synthesized and characterized an inclusion complex of minoxidil with β-cyclodextrin. The results showed the formation of a 1:1 complex between the two components, with a weak interaction in solution. The encapsulation of minoxidil with β-cyclodextrin is believed to increase its solubility and wettability, leading to a supported and gradual release of the drug and maximizing its biodisponibility over time.
