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Glossary Inclusion Complexes

molecule traps another molecule within its structure

Inclusion complexes are structures where one molecule, known as the "host," forms a cavity that can trap another molecule, called the "guest." This can enhance the stability, solubility, or delivery of the guest molecule. For example, in hair care, inclusion complexes can be used to encapsulate active ingredients, making them more effective in treating conditions like alopecia.

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Research

5 / 1000+ results

research Binary and ternary inclusion complexes of finasteride in HPβCD and polymers: Preparation and characterization

37 citations , February 2009 in “Bioorganic & Medicinal Chemistry”

This study suggests that true binary and ternary inclusion complexes were formed between finasteride and 2-hydroxypropyl-ß-cyclodextrin, with or without the addition of specific polymers.

research Synthesis and characterization of inclusion complex of the vasodilator drug minoxidil with β-cyclodextrin

28 citations , April 2008 in “Journal of Inclusion Phenomena and Macrocyclic Chemistry”

This study identified a weak interaction between minoxidil and ß-cyclodextrin in solution, forming an inclusion complex with a 1:1 molar ratio.

Experimental, Molecular Docking Investigations and Bioavailability Study on the Inclusion Complexes of Finasteride and Cyclodextrins

research Experimental, molecular docking investigations and bioavailability study on the inclusion complexes of finasteride and cyclodextrins

23 citations , June 2017 in “Drug Design Development and Therapy”

This study found that the dimethyl-β-cyclodextrin inclusion system significantly improved the solubility and bioavailability of finasteride compared to the drug alone, enhancing its absorption rate.

Physicochemical Characterization of Finasteride: PEG 6000 and Finasteride: Kollidon K25 Solid Dispersions, and Finasteride: Beta-Cyclodextrin Inclusion Complexes

research Physicochemical characterization of finasteride:PEG 6000 and finasteride:Kollidon K25 solid dispersions, and finasteride: β-cyclodextrin inclusion complexes

11 citations , December 2010 in “Journal of Inclusion Phenomena and Macrocyclic Chemistry”

This study found that forming solid dispersions and inclusion complexes of finasteride significantly increased its solubility compared to its pure form.

research Unlocking finasteride's potential via carboxymethyl-β-cyclodextrin inclusion complex for androgenic alopecia

March 2025 in “Carbohydrate Polymer Technologies and Applications”

In this study, researchers developed a carboxylated β-cyclodextrin formulation to enhance finasteride's physicochemical properties, achieving an encapsulation efficiency of about 85% and indicating potential for controlled drug release in therapeutic applications. Their findings suggest this inclusion complex could improve delivery of hydrophobic drugs like finasteride.

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Community Join

5 / 243 results

community An Uncontrolled Case Series Using a Botanically Derived, β-Cyclodextrin Inclusion Complex in Two Androgenetic Alopecia-Affected Male Subjects

1 upvotes 5 years ago

The conversation discusses a botanically derived treatment for androgenetic alopecia using ingredients like saw palmetto, green tea, and evening primrose, showing impressive results over 270 days. Concerns include the study's uncontrolled nature and potential product motivation, with suggestions to enhance absorption through derma rolling.

community 2800 FUE Asmed Koray Erdogan Istanbul, complete failure

in Transplants 287 upvotes 1 year ago

A user had a failed hair transplant with 2800 FUE grafts at a clinic in Turkey, where finasteride was used, and the procedure was poorly executed by technicians rather than the main surgeon. The user later sought repair from a more experienced doctor, highlighting issues with large clinics that handle multiple patients daily.

community Finasteride (4+ Years): Does it actually lose efficacy or stay stable long-term?

in Finasteride/Dutasteride 56 upvotes 1 month ago

Finasteride maintains its efficacy over time, slowing hair loss but not completely stopping it. Long-term users often experience stability, though natural aging may cause gradual decline; additional treatments like minoxidil, RU58841, and others may be needed for aggressive hair loss.

community Who here actually noticed new growth after adding ketoconazole?

in Chat 37 upvotes 1 year ago

Ketoconazole is mainly used for improving scalp health and reducing dandruff, but it is not effective for new hair growth. Some users find it complements treatments like minoxidil and finasteride, but results vary.

community I wanna say this is progress…am I trippin?

in Is this regrowth? 163 upvotes 1 year ago

OP has been using minoxidil (topical 5%) and finasteride (oral 1.25mg daily) for 2 months and is unsure if there's hair regrowth or if it's just a haircut illusion. Mixed responses from others, some see progress, others attribute changes to the haircut.

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