TLDR Polyamines are abundant in certain parts of rat hair follicles and may play a key role in hair growth.
The study examined the expression and distribution of polyamines—spermine, spermidine, and putrescine—in rat hair follicles, revealing that these compounds were most abundant in the matrix, Huxley’s layer, deeper Henle’s layer, and the cuticle of the inner root sheath/hair cuticle. This suggested that these areas had a higher biological potential in anagen hair follicles, potentially playing a critical role in hair growth. Additionally, differences in staining patterns between spermine/spermidine and putrescine in epidermal cells and fibroblasts were observed, indicating possible applications for these findings in researching hair cycles and epidermal tumor genesis.
70 citations,
January 2014 in “International review of cell and molecular biology” Keratin proteins are crucial for healthy skin, but mutations can cause skin disorders with no effective treatments yet.
30 citations,
July 2010 in “Experimental Dermatology” Polyamines are important for hair growth, but more research is needed to understand their functions and treatment potential.
87 citations,
July 2009 in “The journal of investigative dermatology/Journal of investigative dermatology” Human beard hair medulla contains a unique and complex mix of keratins not found in other human tissues.
37 citations,
January 2006 in “Carcinogenesis” Antizyme slows skin tumor growth by reducing cell growth in mice.
24 citations,
June 1999 in “Mechanisms of Development” Ornithine decarboxylase is crucial for hair growth and follicle development.
71 citations,
May 1996 in “Journal of Investigative Dermatology” Ornithine decarboxylase is crucial for hair growth regulation in mice.
42 citations,
February 1996 in “Journal of Investigative Dermatology” Polyamines, especially spermidine, are essential for hair growth.
33 citations,
March 1994 in “PubMed” High ODC and low K1 and K10 may indicate early skin tumors in mice.
34 citations,
October 1975 in “Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis”
