Search

for
Search:

Research

5 / 1000+ results

research Genetically Altered Expression of Spermidine/Spermine N1-Acetyltransferase Affects Fat Metabolism in Mice via Acetyl-CoA

128 citations , December 2006 in “Journal of Biological Chemistry”

This study found that overexpression of the enzyme spermidine/spermine N1-acetyltransferase in mice was associated with increased fat oxidation and a leaner phenotype, while knock-out mice exhibited increased fat accumulation.

research Activated Polyamine Catabolism Depletes Acetyl-CoA Pools and Suppresses Prostate Tumor Growth in TRAMP Mice

91 citations , July 2004 in “Journal of Biological Chemistry”

This study found that overexpression of the enzyme SSAT in a mouse model significantly reduced prostate tumor size and progression, suggesting it could be a promising strategy against prostate cancer.

research Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis

5 citations , February 2025 in “Cell Reports”

In this study, inducible whole-body Acly-knockout mice revealed that ACLY is essential for skin homeostasis, as its deficiency led to increased sebum production and skin abnormalities, indicating a vital role for cytosolic acetyl-CoA synthesis in preserving skin barrier integrity and systemic lipid regulation.

research G.P.2.16 Valproate, acetylcarnitine, folic acid and vitamin B12 in spinal muscular atrophy: Preliminary data of an open-label study in children

1 citations , September 2007 in “Neuromuscular disorders”

This study suggests that long-term treatment with valproate, acetylcarnitine, folic acid, and vitamin B12 may benefit children with SMA types II and III by improving muscle strength and function without significant adverse effects.

research Spermidine/spermine-N¹-acetyltransferase: a key metabolic regulator

305 citations , March 2008 in “AJP Endocrinology and Metabolism”

This article reviews the regulation and roles of spermidine/spermine-N(1)-acetyltransferase (SSAT) in polyamine metabolism and its potential as a target in cancer and other diseases, without reporting new experimental results.

View more "acetyl-coa" in research →

Community Join

5 / 29 results

community IGF-1 and Peptides? Miracle molecule waiting to be found

10 upvotes 1 year ago

The conversation discusses potential hair loss treatments focusing on stimulating IGF-1 at the follicle level using growth-factor cocktails and engineered peptides, such as Acetyl Tetrapeptide-3, Copper Tripeptide-1, Oligopeptide-20, Thymosin-β4, and Palmitoyl Tetrapeptide-7. It suggests that device-assisted delivery methods like microneedling may enhance effectiveness.

community PP405 Won't Work Long Term: Hair Follicle Damage Due to Abuse of the ISR System

67 upvotes 11 months ago

PP405 may damage hair follicles if used long-term, suggesting cycling might be necessary. Combining it with finasteride could help maintain hair growth.

community Finasteride and Eye Problems: You’re Not Going Crazy

in Finasteride/Dutasteride 503 upvotes 1 year ago

Finasteride can cause dry eyes and vision issues due to its impact on the meibomian glands. Users have mixed experiences, with some experiencing eye discomfort and others having no side effects.

community Fats on your Head to Stop Hair Loss?

140 upvotes 2 years ago

The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

community Nice product I discovered, thought I would share.

in Treatment 456 upvotes 1 year ago

A product that makes hair look thicker and healthier without promoting regrowth. Discussions include treatments like minoxidil, finasteride, red light therapy, and a serum with caffeine and peptides, with mixed effectiveness opinions.

View more "acetyl-coa" in community →