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GlossarySirtuin 1

protein involved in aging, stress resistance, and hair growth

Sirtuin 1 (SIRT1) is a protein that plays a crucial role in cellular regulation, including aging, inflammation, and stress resistance. It functions as a deacetylase, removing acetyl groups from proteins, which can affect their activity and stability. SIRT1 is also involved in metabolic processes and has been linked to the regulation of hair growth and the prevention of hair loss, making it a significant focus in studies related to alopecia and other hair disorders.

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research Identification of Sirtuin 1 as a Promising Therapeutic Target for Hypertrophic Scars

36 citations, February 2016 in “British journal of pharmacology”

Sirtuin 1 could be a potential drug target for treating hypertrophic scars.

research Spontaneous Intrinsic Aging in Organ-Cultured Human Skin as a Novel Ex Vivo Assay to Test Anti-Aging Actives

November 2022 in “Journal of Investigative Dermatology”

The document concludes that a new method has been developed to test anti-aging substances on human skin, showing that these substances can reduce skin aging signs.

research Efficacy of an Agonist of α-MSH, the Palmitoyl Tetrapeptide-20, in Hair Pigmentation

12 citations, September 2018 in “International Journal of Cosmetic Science”

Palmitoyl tetrapeptide-20 may help reduce hair greying and increase melanin production.

research MicroRNA-21 in Skin Fibrosis: Potential for Diagnosis and Treatment

32 citations, July 2017 in “Molecular diagnosis & therapy”

MicroRNA-21 could help diagnose and treat skin fibrosis.

research Wound Healing Impairment in Type 2 Diabetes Model of Leptin-Deficient Mice: A Mechanistic Systematic Review

10 citations, August 2022 in “International Journal of Molecular Sciences”

Leptin-deficient mice, used as a model for Type 2 Diabetes, have delayed wound healing due to impaired contraction and other dysfunctional cellular responses.

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community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

in Research/Science 738 upvotes 2 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.