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GlossarySirtuin 1

protein involved in aging, stress resistance, and hair growth

Sirtuin 1 (SIRT1) is a protein that plays a crucial role in cellular regulation, including aging, inflammation, and stress resistance. It functions as a deacetylase, removing acetyl groups from proteins, which can affect their activity and stability. SIRT1 is also involved in metabolic processes and has been linked to the regulation of hair growth and the prevention of hair loss, making it a significant focus in studies related to alopecia and other hair disorders.

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research Spontaneous Intrinsic Aging in Organ-Cultured Human Skin as a Novel Ex Vivo Assay to Test Anti-Aging Actives

November 2022 in “Journal of Investigative Dermatology”

The document concludes that a new method has been developed to test anti-aging substances on human skin, showing that these substances can reduce skin aging signs.

research Efficacy of an Agonist of α-MSH, the Palmitoyl Tetrapeptide-20, in Hair Pigmentation

12 citations , September 2018 in “International Journal of Cosmetic Science”

Palmitoyl tetrapeptide-20 may help reduce hair greying and increase melanin production.

Identification of Dual-Purpose Therapeutic Targets Implicated in Aging and Glioblastoma Multiforme Using PandaOmics - An AI-Enabled Biological Target Discovery Platform

research Identification of Dual-Purpose Therapeutic Targets Implicated in Aging and Glioblastoma Multiforme Using PandaOmics - An AI-Enabled Biological Target Discovery Platform

17 citations , April 2023 in “Aging”

CNGA3, GLUD1, and SIRT1 are promising targets for treating aging and glioblastoma.

research Melatonin Exerts Prominent, Differential Epidermal and Dermal Anti-Aging Properties in Aged Human Eyelid Skin Ex Vivo

21 citations , November 2023 in “International Journal of Molecular Sciences”

Melatonin helps reduce aging signs in human eyelid skin.

research Quercetin and Polycystic Ovary Syndrome

6 citations , December 2022 in “Frontiers in Pharmacology”

Quercetin may help improve symptoms of polycystic ovary syndrome.

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community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

in Research/Science 739 upvotes 3 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.