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GlossarySirtuin 1

protein involved in aging, stress resistance, and hair growth

Sirtuin 1 (SIRT1) is a protein that plays a crucial role in cellular regulation, including aging, inflammation, and stress resistance. It functions as a deacetylase, removing acetyl groups from proteins, which can affect their activity and stability. SIRT1 is also involved in metabolic processes and has been linked to the regulation of hair growth and the prevention of hair loss, making it a significant focus in studies related to alopecia and other hair disorders.

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research Identification of Sirtuin 1 as a Promising Therapeutic Target for Hypertrophic Scars

36 citations , February 2016 in “British journal of pharmacology”

Sirtuin 1 could be a potential drug target for treating hypertrophic scars.

research Spontaneous Intrinsic Aging in Organ-Cultured Human Skin as a Novel Ex Vivo Assay to Test Anti-Aging Actives

November 2022 in “Journal of Investigative Dermatology”

The document concludes that a new method has been developed to test anti-aging substances on human skin, showing that these substances can reduce skin aging signs.

Identification of Dual-Purpose Therapeutic Targets Implicated in Aging and Glioblastoma Multiforme Using PandaOmics - An AI-Enabled Biological Target Discovery Platform

research Identification of Dual-Purpose Therapeutic Targets Implicated in Aging and Glioblastoma Multiforme Using PandaOmics - An AI-Enabled Biological Target Discovery Platform

17 citations , April 2023 in “Aging”

CNGA3, GLUD1, and SIRT1 are promising targets for treating aging and glioblastoma.

Purified Vitexin Compound 1 Inhibits UVA-Induced Cellular Senescence in Human Dermal Fibroblasts by Binding Mitogen-Activated Protein Kinase 1

research Purified Vitexin Compound 1 Inhibits UVA-Induced Cellular Senescence in Human Dermal Fibroblasts by Binding Mitogen-Activated Protein Kinase 1

3 citations , July 2020 in “Frontiers in Cell and Developmental Biology”

Vitexin Compound 1 may help reduce skin aging caused by UVA light.

research Human Genetic Basis of Coronavirus Disease 2019

38 citations , September 2021 in “Signal Transduction and Targeted Therapy”

Genetic differences affect COVID-19 severity and treatment development.

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community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

in Research/Science 733 upvotes 3 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.