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    Glossary Sirtuin 1

    protein involved in aging, stress resistance, and hair growth

    Sirtuin 1 (SIRT1) is a protein that plays a crucial role in cellular regulation, including aging, inflammation, and stress resistance. It functions as a deacetylase, removing acetyl groups from proteins, which can affect their activity and stability. SIRT1 is also involved in metabolic processes and has been linked to the regulation of hair growth and the prevention of hair loss, making it a significant focus in studies related to alopecia and other hair disorders.

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    Research 30 of 243

    1. Identification of sirtuin 1 as a promising therapeutic target for hypertrophic scars British journal of pharmacology · 2016 · 36 citations
    2. 1348 Changes in the aging dermal hair follicle environment in female scalp 2018
    3. 686 Topical melatonin unfolds differential anti-aging effects in human skin by inhibiting mTORC1 activity via TSC2 stimulation Journal of Investigative Dermatology · 2024
    4. 581 Spontaneous, Intrinsic Aging in Organ-Cultured Human Skin as Novel Ex Vivo Assay to Test Candidate Anti-Aging Actives Journal of Investigative Dermatology · 2022
    5. Potential mechanisms of exercise in maintaining skin homeostasis disrupted by protein deficiency (Review) World Academy of Sciences Journal · 2024
    6. Shedding Light on the Effects of Calorie Restriction and Its Mimetics on Skin Biology Nutrients · 2020 · 6 citations
    7. Skinspan: A Holistic Roadmap for Extending Skin Longevity With Evidence‐Based Interventions Journal of Cosmetic Dermatology · 2025 · 1 citations
    8. Molecular Targets in Modern Cosmetic Science Molecules · 2026
    9. Identification of dual-purpose therapeutic targets implicated in aging and glioblastoma multiforme using PandaOmics - an AI-enabled biological target discovery platform Aging · 2023 · 17 citations
    10. Sirtuins pathways and redox homeostasis: a pilot study on young and old monozygotic twins Free Radical Biology and Medicine · 2015
    11. 0871 Skin longevity breakthroughs and targets for cellular age reversal: Sirtuins, key epigenetics regulators Journal of Investigative Dermatology · 2025
    12. The Mitochondrial Blueprint of Skin Aging: From Damage Signals to Dermatologic Interventions Aging and Disease · 2026
    13. Toward Elucidating Epigenetic and Metabolic Regulation of Stem Cell Lineage Plasticity in Skin Aging Frontiers in Cell and Developmental Biology · 2022 · 7 citations
    14. Montagna Symposium 2014—Skin Aging: Molecular Mechanisms and Tissue Consequences 2015 · 9 citations
    15. Redox-directed interventions targeting skin photodamage Free Radical Biology and Medicine · 2015
    16. Purified Vitexin Compound 1 Inhibits UVA-Induced Cellular Senescence in Human Dermal Fibroblasts by Binding Mitogen-Activated Protein Kinase 1 Frontiers in Cell and Developmental Biology · 2020 · 3 citations
    17. The Pathobiology of Skin Aging American Journal Of Pathology · 2020 · 122 citations
    18. 1351 Investigation of the molecular identity of the junctional zone in human 2018
    19. Investigation of the crosstalk between proteasome function and nucleotide excision repair mechanism during ageing Free Radical Biology and Medicine · 2015
    20. Growth Differentiation Factor 11 (GDF11)/Transforming Growth Factor - β (TGF - β)/Mesenchymal Stem Cells (MSCs) Balance: A Complicated Partnership in Skin Rejuvenation Journal of Embryology & Stem Cell Research · 2019 · 1 citations
    21. Anti-aging effects of black raspberry extract on cataract, alopecia, skin whitening, and weight loss Functional Foods in Health and Disease · 2018 · 10 citations
    22. Alopecia areata: from immunopathogenesis to emerging therapeutic approaches Frontiers in Immunology · 2025
    23. Honokiol protects skin cells against inflammation, collagenolysis, apoptosis, and senescence caused by cigarette smoke damage International Journal of Dermatology · 2017 · 20 citations
    24. Investigation the role of SIRT3, SIRT7, NFATC1, and PDL-1 genes in androgenetic alopecia BMC Research Notes · 2024
    25. RETRACTED ARTICLE: Up-regulated lncRNA5322 elevates MAPK1 to enhance proliferation of hair follicle stem cells as a ceRNA of microRNA-19b-3p 2019 · 9 citations
    26. Are Nutraceuticals Effective in COVID-19 and Post-COVID Prevention and Treatment? Foods · 2022 · 12 citations
    27. The Impact of Glucagon-like Peptide-1 Receptor Agonists on Erectile Function: Friend or Foe? Biomolecules · 2025 · 4 citations
    28. Antiviral and Anti-Inflammatory Plant-Derived Bioactive Compounds and Their Potential Use in the Treatment of COVID-19-Related Pathologies Journal of Xenobiotics · 2022 · 26 citations
    29. Post-Acute COVID-19 Sequelae – ‘COVID Long Hauler’ Wits Journal of Clinical Medicine · 2021 · 1 citations
    30. Melatonin Exerts Prominent, Differential Epidermal and Dermal Anti-Aging Properties in Aged Human Eyelid Skin Ex Vivo International Journal of Molecular Sciences · 2023 · 21 citations