Acetyl-CoA Synthesis in the Skin Is a Key Determinant of Systemic Lipid Homeostasis
February 2025
in “
Cell Reports
”
acetyl-CoA ATP-citrate lyase ACLY acetyl-CoA synthetase ACSS2 lipid metabolism epidermis sebaceous glands barrier lipids sebum production fatty acids adipose lipolysis cytosolic acetyl-CoA synthesis skin barrier integrity skin homeostasis lipid production skin abnormalities dietary fat supplementation
TLDR Skin acetyl-CoA synthesis is crucial for overall lipid balance.
The study examines the role of acetyl-CoA synthesis in the skin and its effect on systemic lipid homeostasis using Acly-knockout mice. The absence of ACLY and ACSS2 enzymes leads to skin abnormalities, fat loss, and increased sebum production, with exacerbated effects when both enzymes are missing. This disruption affects epidermal lipid composition, reducing crucial triglycerides and ceramides, yet sebum production increases due to circulating fatty acids. Olive oil supplementation partially mitigates these effects but does not restore the lipid profile. The findings emphasize the skin's critical role in lipid metabolism and its systemic implications, highlighting the need for further research into skin-specific metabolic interactions.
