Acetyl-CoA Synthesis in the Skin Is a Key Determinant of Systemic Lipid Homeostasis

    February 2025 in “ Cell Reports ”
    Phuong Nguyen, Michael H.I. Shiue, Nina Kuprasertkul … Kathryn E. Wellen
    Studysummary In this study, inducible whole-body Acly-knockout mice revealed that ACLY is essential for skin homeostasis, as its deficiency led to increased sebum production and skin abnormalities, indicating a vital role for cytosolic acetyl-CoA synthesis in preserving skin barrier integrity and systemic lipid regulation.
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    Research cited in this study 5

    1. Severe Skin Permeability Barrier Dysfunction in Knockout Mice Deficient in a Fatty Acid Omega-Hydroxylase Crucial to Acylceramide Production Journal of Investigative Dermatology · 2019
    2. The Acyl-CoA Binding Protein Is Required For Normal Epidermal Barrier Function In Mice Journal of Lipid Research · 2012
    3. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    4. Deletion of the Developmentally Essential Gene ATR in Adult Mice Leads to Age-Related Phenotypes and Stem Cell Loss Cell Stem Cell · 2007
    5. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001