Very-Long-Chain Acyl-CoA Synthetases

    November 2007 in “ Journal of Biological Chemistry ”
    Paul A. Watkins
    TLDR Very-long-chain acyl-CoA synthetases and fatty acid transport proteins play key roles in fatty acid metabolism and lipid processing in different tissues.
    The document reviewed the role of very-long-chain acyl-CoA synthetases (ACSVLs) and fatty acid transport proteins (FATPs) in fatty acid metabolism and their implications in diseases such as heart disease, obesity, diabetes, and skin disorders. It highlighted the importance of ACSVLs in activating very-long-chain fatty acids for degradation and discussed the controversy over the dual role of FATPs as synthetases and transporters. The study found that FATP1 was linked to non-shivering thermogenesis and insulin resistance, while FATP4 was associated with skin defects and obesity. The research underscored the need for further investigation into the mechanisms of fatty acid uptake and the physiological functions of ACSVLs and FATPs.
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