Search
forLearn
1 / 1 resultsResearch
5 / 1000+ resultsresearch Acetyl-CoA Synthesis in the Skin Is a Key Determinant of Systemic Lipid Homeostasis
This study investigates the role of ATP-citrate lyase (ACLY) in lipid metabolism by using inducible whole-body Acly-knockout mice. The findings reveal that ACLY is essential for skin homeostasis, as its deficiency leads to upregulation of acetyl-CoA synthetase ACSS2. When both Acly and Acss2 are deleted from the skin, it results in significant skin abnormalities, affecting lipid production in the epidermis and sebaceous glands differently. The epidermis experiences a depletion of barrier lipids, while sebaceous glands increase sebum production, partly due to circulating fatty acids and adipose lipolysis. Dietary fat supplementation enhances sebum production and partially mitigates lipoatrophy and skin abnormalities. The study underscores the importance of cytosolic acetyl-CoA synthesis in skin barrier integrity and positions the skin as a crucial organ in systemic lipid regulation.
research Cell Fate Decisions: Emerging Roles for Metabolic Signals and Cell Morphology
Metabolic signals and cell shape influence how cells develop and change.
research EMT Factors and Metabolic Pathways in Cancer
EMT and metabolic pathways help cancer cells resist treatment and spread.
research Regeneration of Fat Cells from Myofibroblasts During Wound Healing
Some wound-healing cells can turn into fat cells around new hair growth in mice.
research The Paradox of p53: What, How, and Why?
The p53 protein has complex, sometimes contradictory functions, including tumor suppression and promoting cell survival.
Community Join
5 / 114 resultscommunity 57% increased chance of pattern hair loss independently associated with the consumption of sugary beverages in men (p<0.001) Pt 2
Sugary beverages increase the risk of pattern hair loss in men by 57%. Treatments discussed include Minoxidil, finasteride, and RU58841.
community Why can’t we just do another creatine study?
Creatine may worsen hair loss in some, especially with androgenic alopecia, but evidence is mixed. Some users experience no hair loss when using creatine with minoxidil and finasteride, while others notice increased shedding.
community Who's tried these topical solutions?
Topical melatonin, caffeine, and adenosine have shown impressive results in increasing hair density by 55% in 8 weeks, according to a Medium article.
community Physio-metabolic method (antiandrogen, minoxidil, leg training and cold)
by
MagicBold
in Treatments
309 upvotes
1 year ago The method combines finasteride, minoxidil, intense leg exercises, and cold exposure to treat androgenetic alopecia. It aims to boost metabolism and reduce androgenic effects, enhancing hair growth.
community Why creatine and gym cause MPD
Gym and creatine can cause hair loss by increasing testosterone and androgenic activity. DHT blockers may help some, while others need androgen suppression with topical AA like RU or Pyri.