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Glossary Krebs cycle

series of reactions in mitochondria generating cellular energy

The Krebs cycle, also known as the Citric Acid Cycle or TCA cycle, is a series of chemical reactions used by all aerobic organisms to generate energy through the oxidation of acetyl-CoA derived from carbohydrates, fats, and proteins. This cycle takes place in the mitochondria and produces ATP, NADH, and FADH2, which are essential for cellular energy and metabolism.

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research Glucose and acetate metabolism by isolated sheep wool follicles

8 citations , April 1965 in “Archives of biochemistry and biophysics”

This study found that sheep wool follicles actively oxidize acetate and glucose, suggesting the involvement of the TCA cycle for compound synthesis and the potential role of the pentose phosphate pathway in ribose production for RNA and DNA.

research Differential metabolic adaptations define responses of winner and loser oncogenic mutant stem cells in skin epidermisin vivo

2 citations , November 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study found that metabolic adaptations in skin epithelial stem cells, specifically redox ratio recovery and glycolytic flux modulation, define competitive outcomes between wild-type and mutant cells in different oncogenic environments.

research Multiple cyclic nucleotide‐gated channels coordinate calcium oscillations and polar growth of root hairs

56 citations , April 2019 in “The Plant Journal”

This study found that CNGC 6, CNGC 9, and CNGC 14 are crucial for maintaining calcium oscillations necessary for normal root hair growth in plants, with mutations leading to defects like swelling and bursting.

research Human hair follicles operate an internal Cori cycle and modulate their growth via glycogen phosphorylase

30 citations , October 2021 in “Scientific Reports”

This study found that human scalp hair follicles can internally operate a Cori cycle, synthesize glycogen in the presence of lactate, and modulate growth through glycogen phosphorylase activity.

research Effects of dobutamine on cyclic AMP accumulation induced by the stimulation of dopamine receptors in rabbit retina in vitro

3 citations , September 1980 in “Experientia”

In this study, the pharmacological action of dobutamine on rabbit retinae was found to be distinct from that of other dopamine analogs like apomorphine and N-methyl-dopamine.

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community If PP405 goes systemic this would be quite catastrophic

in Research/Science 4 upvotes 1 year ago

Concerns about the potential systemic effects and safety of PP405 for hair loss, with discussions on its comparison to existing treatments like finasteride and minoxidil. Users express skepticism about untested research chemicals and emphasize the importance of clinical trials to ensure safety and efficacy.

community Why creatine and gym cause MPD

in Finasteride/Dutasteride 3 years ago

Gym and creatine can cause hair loss by increasing testosterone and androgenic activity. DHT blockers may help some, while others need androgen suppression with topical AA like RU or Pyri.

community The mechanism of androgenic alopecia

36 upvotes 11 months ago

DHT may inhibit hair growth by affecting mitochondrial function, leading to hair follicle miniaturization. Treatments like minoxidil and PP405 may promote hair growth by altering metabolic pathways, potentially counteracting DHT's effects.

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