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    Glossary Polyamines

    organic compounds crucial for cell growth and function

    Polyamines are organic compounds that play a crucial role in cell growth and function. They are involved in various biological processes, including DNA stabilization, protein synthesis, and cell proliferation. In the context of hair, polyamines like spermidine have been shown to promote hair growth and may help in treating conditions like alopecia.

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    1. Activation of Polyamine Catabolism Profoundly Alters Tissue Polyamine Pools and Affects Hair Growth and Female Fertility in Transgenic Mice Overexpressing Spermidine/SpermineN 1-Acetyltransferase Journal of Biological Chemistry · 1997 · 124 citations
    2. Activated Polyamine Catabolism Depletes Acetyl-CoA Pools and Suppresses Prostate Tumor Growth in TRAMP Mice Journal of Biological Chemistry · 2004 · 91 citations
    3. Promotion of homology-directed DNA repair by polyamines Nature communications · 2019 · 47 citations
    4. Overexpression of spermidine/spermine N1-acetyltransferase under the control of mouse metallothionein I promoter in transgenic mice: evidence for a striking post-transcriptional regulation of transgene expression by a polyamine analogue Biochemical Journal · 1999 · 43 citations
    5. Inhibition of Polyamine Synthesis Alters Hair Follicle Function and Fiber Composition Journal of Investigative Dermatology · 1996 · 42 citations
    6. Trypanocidal Effect of Isotretinoin through the Inhibition of Polyamine and Amino Acid Transporters in Trypanosoma cruzi PLoS neglected tropical diseases · 2017 · 41 citations
    7. Polyamines and hair: a couple in search of perfection Experimental Dermatology · 2010 · 30 citations
    8. Elevated ornithine decarboxylase activity promotes skin tumorigenesis by stimulating the recruitment of bulge stem cells but not via toxic polyamine catabolic metabolites Amino Acids · 2013 · 17 citations
    9. Synthetic studies toward the development of novel minoxidil analogs and conjugates with polyamines Tetrahedron Letters · 2010 · 12 citations
    10. Hairless and the polyamine putrescine form a negative regulatory loop in the epidermis Experimental Dermatology · 2013 · 10 citations
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