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GlossaryHairless Protein

regulates hair growth and follicle cycling

The Hairless Protein, also known as the HR protein, is a crucial component in the regulation of hair growth and development. It is encoded by the HR gene, and mutations in this gene can lead to conditions like alopecia universalis, where individuals lose all body hair. This protein plays a role in the hair follicle cycle, particularly in the transition from the growth phase (anagen) to the rest phase (telogen).

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Diagnostic Value of VDR in Bone Metastasis and Prognosis of Patients with Breast Cancer and Expression Correlation Between Vitamin D Receptor and Hairless Protein

research Diagnostic Value of VDR in Bone Metastasis and Prognosis of Patients with Breast Cancer and Expression Correlation Between Vitamin D Receptor and Hairless Protein

6 citations, November 2021 in “Oncology Research and Treatment”

Low Vitamin D receptor levels in breast cancer are linked to worse outcomes and more bone metastases, and could be a marker for prognosis.

research The Mammalian Hairless Protein as a DNA Binding Phosphoprotein

6 citations, June 2016 in “Journal of cellular biochemistry”

The Hr protein binds to DNA, interacts with p53, and affects cell cycle genes.

research Hairless Triggers Reactivation of Hair Growth by Promoting Wnt Signaling

137 citations, September 2005 in “Proceedings of the National Academy of Sciences of the United States of America”

The HR protein helps hair grow by blocking a hair growth inhibitor, aiding in hair follicle regeneration.

research Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes

78 citations, November 2005 in “Endocrinology”

Hairless protein can block vitamin D activation in skin cells.

research Hairless and Wnt Signaling: Allies in Epithelial Stem Cell Differentiation

74 citations, September 2006 in “Cell Cycle”

The HR protein's role as a repressor is essential for controlling hair growth.

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community Listen to anyone besides your Mom while fighting hair-loss

in Satire 464 upvotes 4 years ago

Hair loss treatments, with people sharing their experiences of trying to get help from family members and how genetics can affect the severity of hair loss. Treatments mentioned include finasteride, minoxidil, RU58841, scalp massage, whey protein and bleaching.

community Is it normal to lose body hair on finasteride?

in Research/Science 11 upvotes 9 months ago

Finasteride can cause body hair loss, which is normal. It may also be due to disease or nutrient deficiencies.

community Keratin microspheres - breakthrough

in Research/Science 13 upvotes 9 months ago

A gel of keratin microspheres promotes hair follicle growth, showing similar effectiveness to minoxidil in mice. The treatment activates hair growth pathways and reduces inflammation, with potential applications in drug delivery for hair-related disorders.

community PYRILUTAMIDE PHASE 3 RESULTS : No statistical significance

in Research/Science 122 upvotes 1 year ago

The phase 3 trial results for Pyrilutamide showed no significant difference from the control treatment in increasing hair count, leading to the company halting its development. Users discussed their disappointment and skepticism about hair loss treatments, with some mentioning other treatments like Minoxidil, Finasteride, and RU58841.

community 1 year on Fin 1 mg. Switching to .4 mg Dut and oral 1.25 mg min

in Progress Pictures 453 upvotes 1 year ago

User shared 1-year progress on Fin 1 mg, switching to 0.4 mg Dut and oral 1.25 mg Min. Good results with Fin, biotin supplement, and biotin shampoo; trying Dut and oral Min for potential better results.

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