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GlossaryHairless Protein

regulates hair growth and follicle cycling

The Hairless Protein, also known as the HR protein, is a crucial component in the regulation of hair growth and development. It is encoded by the HR gene, and mutations in this gene can lead to conditions like alopecia universalis, where individuals lose all body hair. This protein plays a role in the hair follicle cycle, particularly in the transition from the growth phase (anagen) to the rest phase (telogen).

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Diagnostic Value of VDR in Bone Metastasis and Prognosis of Patients with Breast Cancer and Expression Correlation Between Vitamin D Receptor and Hairless Protein

research Diagnostic Value of VDR in Bone Metastasis and Prognosis of Patients with Breast Cancer and Expression Correlation Between Vitamin D Receptor and Hairless Protein

6 citations , November 2021 in “Oncology Research and Treatment”

Low Vitamin D receptor levels in breast cancer are linked to worse outcomes and more bone metastases, and could be a marker for prognosis.

research The Mammalian Hairless Protein as a DNA Binding Phosphoprotein

6 citations , June 2016 in “Journal of cellular biochemistry”

The Hr protein binds to DNA, interacts with p53, and affects cell cycle genes.

research Physical And Functional Interaction Between The Vitamin D Receptor And Hairless Corepressor, Two Proteins Required For Hair Cycling

215 citations , September 2003 in “Journal of Biological Chemistry”

Vitamin D receptor and hairless protein are essential for hair growth.

research Hairless Triggers Reactivation of Hair Growth by Promoting Wnt Signaling

137 citations , September 2005 in “Proceedings of the National Academy of Sciences of the United States of America”

The HR protein helps hair grow by blocking a hair growth inhibitor, aiding in hair follicle regeneration.

research Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes

78 citations , November 2005 in “Endocrinology”

Hairless protein can block vitamin D activation in skin cells.

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community Great news recently for people with hairloss!

in Research/Science 113 upvotes 5 months ago

A potential treatment for alopecia involving a protein that calms hair follicles has shown promise in rats, but skepticism remains about its applicability to humans. Many users express doubt about the timeline for effective hair loss treatments, comparing it to past unfulfilled promises.

community Listen to anyone besides your Mom while fighting hair-loss

in Satire 464 upvotes 4 years ago

Hair loss treatments, with people sharing their experiences of trying to get help from family members and how genetics can affect the severity of hair loss. Treatments mentioned include finasteride, minoxidil, RU58841, scalp massage, whey protein and bleaching.

community Is it normal to lose body hair on finasteride?

in Research/Science 11 upvotes 1 year ago

Finasteride can cause body hair loss, which is normal. It may also be due to disease or nutrient deficiencies.

community Keratin microspheres - breakthrough

in Research/Science 14 upvotes 1 year ago

A gel of keratin microspheres promotes hair follicle growth, showing similar effectiveness to minoxidil in mice. The treatment activates hair growth pathways and reduces inflammation, with potential applications in drug delivery for hair-related disorders.

community PYRILUTAMIDE PHASE 3 RESULTS : No statistical significance

in Research/Science 123 upvotes 1 year ago

The phase 3 trial results for Pyrilutamide showed no significant difference from the control treatment in increasing hair count, leading to the company halting its development. Users discussed their disappointment and skepticism about hair loss treatments, with some mentioning other treatments like Minoxidil, Finasteride, and RU58841.

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