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Glossary Hairless Protein

regulates hair growth and follicle cycling

The Hairless Protein, also known as the HR protein, is a crucial component in the regulation of hair growth and development. It is encoded by the HR gene, and mutations in this gene can lead to conditions like alopecia universalis, where individuals lose all body hair. This protein plays a role in the hair follicle cycle, particularly in the transition from the growth phase (anagen) to the rest phase (telogen).

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Research

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research Human Hairless Protein Roles in Skin/Hair and Emerging Connections to Brain and Other Cancers

15 citations , May 2017 in “Journal of Cellular Biochemistry”

This review discusses the role of the hairless protein (HR) in alopecia and cancer, noting its potential importance in cancer cell growth and survival, and reports no new experimental results.

Diagnostic Value of VDR in Bone Metastasis and Prognosis of Patients with Breast Cancer and Expression Correlation Between Vitamin D Receptor and Hairless Protein

research Diagnostic Value of VDR in Bone Metastasis and Prognosis of Patients with Breast Cancer and Expression Correlation between Vitamin D Receptor and Hairless Protein

6 citations , November 2021 in “Oncology Research and Treatment”

This study found that lower expression of VDR protein in breast cancer patients is associated with increased bone metastasis and poorer prognosis, making it a significant prognostic factor.

research The Mammalian Hairless Protein as a DNA Binding Phosphoprotein

6 citations , June 2016 in “Journal of cellular biochemistry”

This study found that the mammalian Hr protein can interact with the p53 pathway by binding to a specific p53 response element, influencing the regulation of genes involved in cell cycle control.

research Mechanism of JmjC-containing protein Hairless in the regulation of vitamin D receptor function

5 citations , September 2011 in “Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease”

Hairless protein helps control hair growth by regulating vitamin D receptor activity.

research Hairless protein of Jumonji family and hair loss

January 2009

This article reviews the role of the hairless protein in hair cycling and gene regulation, noting the need for further understanding of its JmjC domain and subcellular localization roles.

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Community Join

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community Whey Protein can cause hairloss in men with AGA as per a doctor

64 upvotes 8 months ago

Whey protein may slightly increase hair loss in men with androgenetic alopecia (AGA) due to elevated IGF-1 and testosterone levels, but the effect is minimal compared to treatments like finasteride and dutasteride. Many users argue that whey protein's impact on hair loss is negligible and that maintaining a healthy lifestyle is more important.

community Great news recently for people with hairloss!

in Research/Science 113 upvotes 1 year ago

A potential treatment for alopecia involving a protein that calms hair follicles has shown promise in rats, but skepticism remains about its applicability to humans. Many users express doubt about the timeline for effective hair loss treatments, comparing it to past unfulfilled promises.

community Hairloss all over body and head

4 upvotes 8 months ago

A 25-year-old experiencing hair thinning all over the body and head, despite using minoxidil and having low vitamin D levels, is advised to seek a second opinion from a dermatologist specializing in hair loss. The likely diagnosis is diffuse alopecia areata, which may require treatment with a JAK inhibitor.

community Whey protein and hair loss

6 upvotes 9 years ago

Whey protein does not cause hair loss; concerns are likely unfounded. The user is on finasteride and minoxidil but sees no improvement, so they are phasing out these treatments while continuing to work out and use whey protein.

community Hairloss Guidance - Female ( FPHL + TE)

10 upvotes 2 days ago

A 27-year-old woman with advanced female pattern hair loss and telogen effluvium is experiencing increased hair shedding after starting oral minoxidil and finasteride. She is seeking advice and reassurance from others who have experienced similar issues, while also considering additional treatments like dermapen and ensuring her nutritional needs are met.

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Learn

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signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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