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    Glossary Hairless Protein

    regulates hair growth and follicle cycling

    The Hairless Protein, also known as the HR protein, is a crucial component in the regulation of hair growth and development. It is encoded by the HR gene, and mutations in this gene can lead to conditions like alopecia universalis, where individuals lose all body hair. This protein plays a role in the hair follicle cycle, particularly in the transition from the growth phase (anagen) to the rest phase (telogen).

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    1. Human Hairless Protein Roles in Skin/Hair and Emerging Connections to Brain and Other Cancers Journal of Cellular Biochemistry · 2017 · 15 citations
    2. Diagnostic Value of VDR in Bone Metastasis and Prognosis of Patients with Breast Cancer and Expression Correlation between Vitamin D Receptor and Hairless Protein Oncology Research and Treatment · 2021 · 6 citations
    3. The Mammalian Hairless Protein as a DNA Binding Phosphoprotein Journal of cellular biochemistry · 2016 · 6 citations
    4. Mechanism of JmjC-containing protein Hairless in the regulation of vitamin D receptor function Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 2011 · 5 citations
    5. Hairless protein of Jumonji family and hair loss 2009
    6. Physical and Functional Interaction between the Vitamin D Receptor and Hairless Corepressor, Two Proteins Required for Hair Cycling Journal of Biological Chemistry · 2003 · 215 citations
    7. Arabidopsis ZINC FINGER PROTEIN1 Acts Downstream of GL2 to Repress Root Hair Initiation and Elongation by Directly Suppressing bHLH Genes The Plant Cell · 2019 · 101 citations
    8. Hairless triggers reactivation of hair growth by promoting Wnt signaling Proceedings of the National Academy of Sciences of the United States of America · 2005 · 137 citations
    9. Hairless Suppresses Vitamin D Receptor Transactivation in Human Keratinocytes Endocrinology · 2005 · 78 citations
    10. Hairless and Wnt Signaling: Allies in Epithelial Stem Cell Differentiation Cell Cycle · 2006 · 74 citations
    11. Novel Hairless Mutations in Two Kindreds with Autosomal Recessive Papular Atrichia Journal of Investigative Dermatology · 1999 · 66 citations
    12. Hairless is a nuclear receptor corepressor essential for skin function Nuclear Receptor Signaling · 2009 · 30 citations
    13. A Novel Missense Mutation Affecting the Human Hairless Thyroid Receptor Interacting Domain 2 Causes Congenital Atrichia Journal of Investigative Dermatology · 2002 · 26 citations
    14. Analysis of hairless corepressor mutants to characterize molecular cooperation with the vitamin D receptor in promoting the mammalian hair cycle Journal of Cellular Biochemistry · 2010 · 22 citations
    15. A novel missense mutation in the mouse hairless gene causes irreversible hair loss: Genetic and molecular analyses of Hrm1Enu Genomics · 2006 · 18 citations
    16. Hairless and the polyamine putrescine form a negative regulatory loop in the epidermis Experimental Dermatology · 2013 · 10 citations
    17. Commentary on: Hairless and the polyamine putrescine form a negative regulatory loop in the epidermis Experimental Dermatology · 2013 · 5 citations
    18. The “Bald Mill Hill” Mutation in the Mouse Is Associated with an Abnormal, Mislocalized HR bmh Protein Journal of Investigative Dermatology · 2007 · 1 citations
    19. Hair Follicle Disruption Facilitates Pathogenesis to UVB-Induced Cutaneous Inflammation and Basal Cell Carcinoma Development in Ptch+/− Mice American Journal of Pathology · 2014 · 8 citations
    20. Hairless: A nuclear receptor corepressor essential for skin function Advances in developmental biology · 2006
    21. Interactions of the Vitamin D Receptor with the Corepressor Hairless Journal of Biological Chemistry · 2007 · 42 citations
    22. Atrichia with papular lesions resulting from a novel insertion mutation in the human hairless gene Clinical and Experimental Dermatology · 2006 · 19 citations
    23. Kyoto Rhino Rats Derived by ENU Mutagenesis Undergo Congenital Hair Loss and Exhibit Focal Glomerulosclerosis EXPERIMENTAL ANIMALS · 2011 · 9 citations
    24. Poly(rC) binding protein 2 acts as a negative regulator of IRES-mediated translation of Hr mRNA 2018 · 3 citations
    25. Relationship of a Novel c.429delC Deletion in Hairless Gene HR with Alopecia in Two Families from Southern Punjab, Pakistan Pakistan Journal of Zoology · 2020
    26. A discourse on human hair fibers and reflections on the conservation of drug molecules International Journal of Legal Medicine · 1996 · 47 citations
    27. The abnormal, mis-localizated HR bmh protein associates with members of the protein processing machinery in the cytoplasm bioRxiv (Cold Spring Harbor Laboratory) · 2018
    28. Analyse de la régulation du gène Hairless et identification des voies de signalisation affectées chez les mutants «bald Mill Hill». HAL (Le Centre pour la Communication Scientifique Directe) · 2008
    29. Therapeutic strategy for hair regeneration: hair cycle activation, niche environment modulation, wound-induced follicle neogenesis, and stem cell engineering Expert Opinion on Biological Therapy · 2013 · 74 citations
    30. 600 Evaluation of anti-hairloss shampoo through in vitro activity in human hair follicule dermal papilla cells and sensorial study 2021