TLDR The Hr protein binds to DNA, interacts with p53, and affects cell cycle genes.
The study investigated the mammalian hairless (Hr) protein, revealing its specific binding to a p53 response element (p53RE) and its interaction with the p53 protein, which influences the regulation of cell cycle control genes GADD45A and p21. Chromatin immunoprecipitation (ChIP) assays confirmed HR binding to the p53RE of the GADD45A gene in HEK293 and U87 cells. Co-immunoprecipitation assays showed direct interaction between HR and p53. Additionally, Hr was found to be a substrate for PKC but not PKA, with human HR phosphorylated at Ser-416 in U87 cells. These findings suggested that Hr is a phosphoprotein involved in the p53 pathway, impacting cell proliferation and differentiation in skin and brain tissues.
17 citations,
May 2012 in “Journal of biological chemistry/The Journal of biological chemistry” Hairless protein affects hair follicle structure by regulating the Dlx3 gene.
30 citations,
January 2009 in “Nuclear Receptor Signaling” Hairless protein is crucial for healthy skin and hair, and its malfunction can cause hair loss.
1 citations,
March 2024 in “Signal transduction and targeted therapy” NF-κB signaling is crucial in many diseases and can be targeted for new treatments.
19 citations,
December 2015 in “Journal of Investigative Dermatology” The protein p53 directly reduces the production of Keratin 17, a skin and hair protein, in rats with radiation dermatitis.
January 2018 in “Elsevier eBooks” The document concludes that alopecia has significant social and psychological effects, leading to a market for hair loss treatments.
70 citations,
February 2015 in “Expert Opinion on Drug Discovery” Topical drugs and near-infrared light therapy show potential for treating alopecia.
11 citations,
October 2021 in “Frontiers in Cell and Developmental Biology” Non-coding RNAs are important for hair growth and could lead to new hair loss treatments, but more research is needed.
