Hairless Plays a Role in Formation of Inner Root Sheath via Regulation of Dlx3 Gene

May 2012 in “ Journal of biological chemistry/The Journal of biological chemistry ”

Bong Kyu Kim, Hwa Young Lee, Jee Hyun Choi, Jeong Ki Kim, Jong Bok Yoon, Sungjoo Kim Yoon

Hairless gene HR gene inner root sheath IRS Dlx3 gene IRS keratin genes Krt25 Krt27 Krt28 Krt71 hair follicles hair growth hair loss HR

TLDR Hairless protein affects hair follicle structure by regulating the Dlx3 gene.

The study concluded that the Hairless (HR) gene played a crucial role in the formation of the inner root sheath (IRS) of hair follicles by regulating the Dlx3 gene. Mutations in the Hr gene led to defects in IRS development, affecting hair growth and maintenance. HR down-regulated Dlx3 expression, which in turn suppressed IRS keratin genes (Krt25, Krt27, Krt28, and Krt71), leading to abnormal IRS formation and hair follicle abnormalities. The research provided insights into the genetic mechanisms underlying hair growth and potential targets for treating hair loss conditions.

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