Hairless Plays a Role in Formation of Inner Root Sheath via Regulation of Dlx3 Gene

    Bong Kyu Kim, Hwa Young Lee, Jee Hyun Choi, Jeong Ki Kim, Jong Bok Yoon, Sungjoo Kim Yoon
    TLDR Hairless protein affects hair follicle structure by regulating the Dlx3 gene.
    The study concluded that the Hairless (HR) gene played a crucial role in the formation of the inner root sheath (IRS) of hair follicles by regulating the Dlx3 gene. Mutations in the Hr gene led to defects in IRS development, affecting hair growth and maintenance. HR down-regulated Dlx3 expression, which in turn suppressed IRS keratin genes (Krt25, Krt27, Krt28, and Krt71), leading to abnormal IRS formation and hair follicle abnormalities. The research provided insights into the genetic mechanisms underlying hair growth and potential targets for treating hair loss conditions.
    Discuss this study in the Community →

    Research cited in this study

    11 / 11 results

    Related Community Posts Join

    6 / 1000+ results

      community Does whey protein and creatine aggravate hair loss?

      in Research/Science  82 upvotes 1 year ago
      The conversation discusses whether whey protein and creatine worsen hair loss. Some users report hair loss with creatine use, while others do not; opinions on whey protein's effects are mixed. Treatments mentioned include PRP, minoxidil, and finasteride.

      community Creatine's effect on Hair Loss and DHT

      in Research/Science  102 upvotes 9 months ago
      A 21-year-old male managed to control his hair loss using Nizoral, RU58841, and finasteride, but experienced increased scalp itchiness after starting creatine, which subsided upon stopping creatine. Users shared mixed experiences on whether creatine affects hair loss, with some reporting negative effects and others seeing no change or defending its benefits.

      community Should I dedicate my university studies to solving hair loss?

      in Research/Science  373 upvotes 1 year ago
      A 20 year old male who is balding and considering switching to a biology/chemistry program in order to find a low-cost, accessible solution for hair loss. Replies discuss the merits of this idea as well as potential treatments such as Minoxidil, finasteride, RU58841, TM5614, and ADQ.

      community Testosterone in Reference Range Doesn't Cause Hair Loss

      in Research/Science  51 upvotes 10 months ago
      Testosterone within the normal range does not significantly contribute to male pattern baldness (MPB); DHT is the main factor that can be controlled. Genetics play a crucial role in hair loss, and treatments like finasteride and dutasteride, which block DHT, can help despite potentially raising testosterone levels.

      community PYRILUTAMIDE PHASE 3 RESULTS : No statistical significance

      in Research/Science  122 upvotes 1 year ago
      The phase 3 trial results for Pyrilutamide showed no significant difference from the control treatment in increasing hair count, leading to the company halting its development. Users discussed their disappointment and skepticism about hair loss treatments, with some mentioning other treatments like Minoxidil, Finasteride, and RU58841.

      community What would hair loss treatment be like in the 2030s?

      in Treatment  5 upvotes 5 months ago
      The conversation discusses future hair loss treatments, with mentions of dutasteride potentially gaining FDA approval and increased popularity. Skepticism remains about significant advancements due to limited funding and reliance on cosmetic companies.

    Related Research

    2 / 2 results