TLDR The Hairless gene is crucial for hair cell development, affecting whether skin cells become hair or skin and oil gland cells.
The study demonstrated that the Hairless (Hr) gene is essential for the differentiation of progenitor keratinocytes into hair keratinocytes via the Wnt/β-catenin signaling pathway. In the absence of the Hr gene, these progenitor cells were found to differentiate into epidermal and sebaceous gland cells instead, indicating a disruption in normal hair follicle development. The research, which included skin samples from 12-day-old mutant mice (n = 3), suggests that the Hr gene's regulation of Wnt/β-catenin signaling is critical for hair follicle fate determination. This has potential implications for understanding and treating hair loss disorders such as androgenetic alopecia (AGA) and alopecia areata (AA). The study was supported by the National Natural Science Foundation of China.
14 citations,
July 2015 in “Journal of Cosmetic Dermatology” Sebaceous glands in male pattern hair loss patients have more lobules and might cause early hair growth phase shifts.
60 citations,
April 2012 in “Physiology” The document concludes that understanding hair and feather regeneration can help develop new regenerative medicine strategies.
717 citations,
June 2010 in “Nature” Alopecia areata involves both innate and adaptive immunity, with specific genes linked to the disease.
181 citations,
January 2009 in “Nature Genetics” Certain mutations in a hair growth-related gene cause a type of genetic hair loss.
30 citations,
January 2009 in “Nuclear Receptor Signaling” Hairless protein is crucial for healthy skin and hair, and its malfunction can cause hair loss.
74 citations,
September 2006 in “Cell Cycle” The HR protein's role as a repressor is essential for controlling hair growth.
42 citations,
June 2019 in “Aging” 3,4,5-tri-O-caffeoylquinic acid promotes hair growth by activating the β-catenin pathway.
6 citations,
July 2017 in “Biochemical and Biophysical Research Communications” The Hairless gene is crucial for hair cell development, affecting whether skin cells become hair or skin and oil gland cells.
26 citations,
July 2016 in “PLOS ONE” Activating β-catenin in certain skin cells speeds up hair growth in mice.
19 citations,
January 2013 in “International journal of medical sciences” Increasing Wnt5a in mice skin delays hair growth but doesn't stop it.
314 citations,
April 2010 in “Developmental Cell” β-catenin in the dermal papilla is crucial for normal hair growth and repair.
137 citations,
September 2005 in “Proceedings of the National Academy of Sciences of the United States of America” The HR protein helps hair grow by blocking a hair growth inhibitor, aiding in hair follicle regeneration.
