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Glossary Hair Keratinocytes

specialized cells in hair follicles producing structural protein keratin

Hair keratinocytes are specialized cells found in the hair follicle that produce keratin, a protein that forms the structural foundation of hair. These cells play a crucial role in the growth and strength of hair, as they continuously divide and differentiate to form the hair shaft.

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Research

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research Cyclosporin A-induced hair growth in mice is associated with inhibition of calcineurin-dependent activation of NFAT in follicular keratinocytes

57 citations , June 2003 in “American Journal of Physiology-cell Physiology”

This study found that cyclosporin A treatment enhances hair growth in mice by inhibiting calcineurin-NFAT1 activity, which alters keratinocyte differentiation and apoptosis-related gene expression in hair follicles.

research Fructose-1,6-bisphosphate aldolase A levels decrease in hair keratinocytes during androgenetic alopecia

2 citations , January 2013 in “International Journal of Dermatology”

ALDOA levels drop in hair cells during hair loss.

research 1435 Enzymatic digestion of scalp hair follicle bulge allows to have more bulge-derived stem keratinocytes than explant isolation

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that using trypsin digestion to extract keratinocytes from the hair follicle bulge results in a higher yield and faster growth of stem keratinocytes compared to the explant method.

research Decorin promotes proliferation and migration of ORS keratinocytes and maintains hair anagen in mice

10 citations , August 2018 in “Experimental Dermatology”

This study found that DECORIN promotes the proliferation and migration of outer root sheath keratinocytes in vitro and maintains the hair anagen phase in mice.

research Cystine-thiamin-containing hair-growth formulation modulates the response to UV radiation in an in vitro model for growth-limiting conditions of human keratinocytes

9 citations , September 2018 in “Journal of Photochemistry and Photobiology B-biology”

This study demonstrated that combining l-cystine and thiamin in a formulation may protect against UV-induced damage in growth-limited human epidermal keratinocytes in vitro.

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Community Join

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community Minoxidil Response Bottlenecks: Why Sulfation and Transport Matter (And Where Tretinoin Fits In)

in Research 461 upvotes 1 year ago

Minoxidil's effectiveness is limited by the need for sulfation and proper transport to hair follicles, with tretinoin potentially enhancing its effects by promoting enzyme activity and keratinocyte differentiation. Tretinoin may improve minoxidil's response by boosting the expression of necessary enzymes and transporters.

community Hair repigmentation of poliosis circumscripta in androgenetic alopecia patient treated with exosomes and fractional picosecond laser

2 upvotes 2 years ago

Exosomes combined with fractional picosecond laser treatment were effective in treating androgenetic alopecia and promoting repigmentation in white hair patches. The role of exosomes in hair repigmentation, particularly in conditions like poliosis, is not well-studied.

community Hair Loss Inflammation Prevention Stack

48 upvotes 1 year ago

The conversation discusses a hair loss and scalp care routine involving ciclopirox shampoo, benzoyl peroxide, clindamycin gel, clobetasol propionate, and calcipotriol to manage seborrheic dermatitis, folliculitis, and inflammation. It also touches on the role of diet and other treatments like oral minoxidil and pioglitazone for scalp health.

community Short Peptides for Hair Loss: anyone tried any of these?

14 upvotes 5 months ago

Various peptides are discussed for treating male pattern baldness, with some available for topical use like GHK-Cu and Ac-KGHK, while others remain in research stages. Users are interested in experiences and sourcing these treatments.

community DHT Isn’t the Only Factor in Hair Loss and That Might Be the Key to a Real Cure

373 upvotes 6 months ago

Hair loss involves more than just DHT, with genetic factors like TRPS affecting hair follicles. Treatments such as Amplifica's AMP-601 and AMP-303 target stem cells for potential hair growth solutions.

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Learn

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learn Redensyl

commercial product with a blend of mostly natural ingredients for hair regrowth

learn Melatonin

hormone commonly taken for sleep aid has some topical benefits for hair

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Procyanidin

bioflavonoid found in plants with antioxidant and hair stimulating properties

learn Follistatin

glycoprotein that inhibits TGF-β and promotes hair growth by antagonizing activin

learn Hair Fibers

Do hair fibers really make thinning hair look fuller, or is it just an illusion? Hair fibers create an optical illusion of fullness but do not actually thicken hair.
How do you apply hair fibers correctly so they stay in place all day? Apply hair fibers to clean, dry hair and use a setting spray for better hold.
Can hair fibers be used along with medical treatments like minoxidil or finasteride? Yes, hair fibers can be used with minoxidil or finasteride without any chemical interaction.
All 5 questions on Hair Fibers →

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Clinics

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Experts

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SMP Specialist
Hairo Fallas
Newark, NJ, United States

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Hairo Fallas