Damage of Hair Follicle Stem Cells and Alteration of Keratin Expression in External Radiation-Induced Acute Alopecia

    June 2012 in “ International Journal of Molecular Medicine ”
    Naoki Nanashima, Koichi Ito, Takashi Ishikawa, Manabu Nakano, Toshiya Nakamura
    TLDR Radiation damages hair stem cells and changes keratin expression, with Krt5 as a potential marker for radiation effects.
    The study examined the impact of 6 Gy X-ray radiation on hair follicle stem cells and keratin expression in mice, leading to acute alopecia. It found no changes in major hair keratins but observed a decrease in Krt15 and CD34, markers of hair follicle stem cells, and an increase in Krt5, a marker for basal keratinocytes, in the epidermis of alopecic mice. This suggested that radiation damaged hair stem cells and altered keratinocyte differentiation. The study proposed Krt5 as a potential novel marker for acute radiation symptoms, emphasizing its increased expression in affected mice.
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