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GlossaryKeratin 5

protein providing structural support in skin and hair follicles

Keratin 5 (KRT5) is a type of protein found in the skin and hair follicles that helps provide structural support and strength. It is particularly important in the formation of the intermediate filaments in epithelial cells, which are cells that line the surfaces and cavities of the body. Mutations in the KRT5 gene can lead to skin disorders such as epidermolysis bullosa simplex, where the skin becomes fragile and blisters easily.

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research Damage of hair follicle stem cells and alteration of keratin expression in external radiation-induced acute alopecia

28 citations , June 2012 in “International Journal of Molecular Medicine”

Radiation damages hair stem cells and changes keratin expression, with Krt5 as a potential marker for radiation effects.

research Neuroendocrinology of Epithelial Hair Follicle Stem Cells

42 citations , March 2008 in “Molecular and Cellular Endocrinology”

Hormones and neuroendocrine factors control hair growth and color, and more research could lead to new hair treatment options.

research The Germinative Epithelium of Sheep Vibrissae and Wool Follicles Has Extensive Proliferative Potential but Is Dependent on the Dermal Papilla

1 citations , January 2012 in “International journal of trichology”

Sheep hair follicle cells can grow a lot but need the dermal papilla to do so.

Establishment and Characterization of Matched Immortalized Human Frontal and Occipital Scalp Dermal Papilla Cell Lines from Androgenetic Alopecia

research Establishment and Characterization of Matched Immortalized Human Frontal and Occipital Scalp Dermal Papilla Cell Lines from Androgenetic Alopecia

December 2023 in “Scientific Reports”

Scientists created cell lines from balding patients and found that cells from the front of the scalp are more affected by hormones that cause hair loss than those from the back.

research Tracing Immune Cells Around Biomaterials With Spatial Anchors During Large-Scale Wound Regeneration

September 2023 in “Nature Communications”

Immune cells are essential for skin regeneration using biomaterial scaffolds.

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