Cytokeratin 15 Expression in Trichoepitheliomas and a Subset of Basal Cell Carcinomas Suggests They Originate from Hair Follicle Stem Cells

    March 1999 in “ Journal of Cutaneous Pathology ”
    Debra M. Jih, Stephen Lyle, Rosalie Elenitsas … George Cotsarelis
    Studysummary This study found that keratin 15 expression in trichoepitheliomas and some basal cell carcinomas suggests a link to hair follicle stem cells in the bulge.
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    Research cited in this study 8

    1. Onset of Keratin 17 Expression Coincides with the Definition of Major Epithelial Lineages During Skin Development The Journal of Cell Biology · 1998
    2. Activation of the Transcription Factor Gli1 and the Sonic Hedgehog Signaling Pathway in Skin Tumors Nature · 1997
    3. Characterization of Hair Follicle Bulge in Human Fetal Skin: The Human Fetal Bulge Is a Pool of Undifferentiated Keratinocytes Journal of Investigative Dermatology · 1995
    4. Expression of the Bcl-2 Proto-Oncogene in the Cycling Adult Mouse Hair Follicle Journal of Investigative Dermatology · 1994
    5. Apoptosis in Human Skin Development: Morphogenesis, Periderm, and Stem Cells Developmental dynamics · 1994
    6. Solid Basal Cell Epithelioma Possibly Originates From the Outer Root Sheath of the Hair Follicle PubMed · 1993
    7. Keratin Expression in Basal Cell Carcinomas British Journal of Dermatology · 1992
    8. Ultrastructural Resemblance of Basal Cell Epithelioma to Primary Epithelial Germ Journal of Cutaneous Pathology · 1978

    Related research 8

    1. Keratin-Mediated Hair Growth and Its Underlying Biological Mechanism Communications biology · 2022
    2. Expression of Caspase-14 and Keratin-19 in the Human Epidermis and Appendages During Fetal Skin Development Archives of Dermatological Research · 2013
    3. Expression of E6 and E7 Papillomavirus Oncogenes in the Outer Root Sheath of Hair Follicles Extends the Growth Phase and Bypasses Resting at Telogen PubMed · 2000
    4. Effects of Epidermal Growth Factor on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1994
    5. Keratin Expression in Basal Cell Carcinomas British Journal of Dermatology · 1992
    6. Expression of Keratin K14 in the Epidermis and Hair Follicle: Insights Into Complex Programs of Differentiation The Journal of Cell Biology · 1989
    7. Keratins of the Human Hair Follicle: Hyperproliferative Keratins Consistently Expressed in Outer Root Sheath Cells In Vivo and In Vitro Differentiation · 1987
    8. Citrulline-Containing Basal Cell Carcinomas: Differentiation Toward Hair Structures With Induction of Dermal Hair Papillae Cancer · 1968