Keratin-Mediated Hair Growth and Its Underlying Biological Mechanism

    November 2022 in “ Communications biology ”
    Seokyung An, Hyosung Kim, So Yeon Kim … Yu‐Shik Hwang
    Studysummary This study found that injecting keratin into the skin of mice promoted hair growth, potentially through keratin's interaction with hair-forming cells and changes in the microenvironment.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 23

    1. Transcriptome Profiling and Differential Gene Expression in Canine Microdissected Anagen and Telogen Hair Follicles and Interfollicular Epidermis Genes · 2020
    2. Stimulation of Hair Growth by Small Molecules That Activate Autophagy Cell reports · 2019
    3. Hedgehog Stimulates Hair Follicle Neogenesis by Creating Inductive Dermis During Murine Skin Wound Healing Nature Communications · 2018
    4. Review of Hair Follicle Dermal Papilla Cells as In Vitro Screening Model for Hair Growth International Journal of Cosmetic Science · 2018
    5. The Mesenchymal Niche of the Hair Follicle Induces Regeneration by Releasing Primed Progenitors from Inhibitory Effects of Quiescent Stem Cells Cell Reports · 2018
    6. Stem Cell Plasticity Enables Hair Regeneration Following Lgr5+ Cell Loss Nature Cell Biology · 2017
    7. Gata6 Promotes Hair Follicle Progenitor Cell Renewal by Genome Maintenance During Proliferation The EMBO Journal · 2016
    8. Resting No More: Redefining Telogen, the Maintenance Stage of the Hair Growth Cycle Biological Reviews · 2014
    9. Human Hair Keratin and Its-Based Biomaterials for Biomedical Applications Jo'jig gonghag gwa jaesaeng uihag/Tissue engineering and regenerative medicine · 2014
    10. Stem Cell Dynamics in the Hair Follicle Niche Seminars in Cell & Developmental Biology · 2013
    11. Keratin 79 Identifies a Novel Population of Migratory Epithelial Cells That Initiates Hair Canal Morphogenesis and Regeneration Development · 2013
    12. Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth Proceedings of the National Academy of Sciences of the United States of America · 2013
    13. Identification of Telogen Markers Underscores That Telogen Is Far from a Quiescent Hair Cycle Phase ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2011
    14. Sox2-Positive Dermal Papilla Cells Specify Hair Follicle Type in Mammalian Epidermis Development · 2009
    15. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    16. Keratin Expression Provides Novel Insight Into the Morphogenesis and Function of the Companion Layer in Hair Follicles Journal of Investigative Dermatology · 2006
    17. Keratin 17 Modulates Hair Follicle Cycling in a TNFα-Dependent Fashion Genes & Development · 2006
    18. The Hair Cycle Journal of Cell Science · 2006
    19. Hair Follicle Differentiation And Regulation The International Journal of Developmental Biology · 2004
    20. Apoptosis and Keratin Intermediate Filaments Cell Death and Differentiation · 2002
    21. The Chemotactic Effect of a Dermal Papilla Cell-Derived Factor on Outer Root Sheath Cells Journal of Dermatological Science · 2001
    22. Manipulation of Outer Root Sheath Cell Survival Perturbs the Hair-Growth Cycle The EMBO Journal · 1999
    23. The Catalog of Human Hair Keratins Journal of biological chemistry/˜The œJournal of biological chemistry · 1999

    Related research 4

    1. Keratin-Mediated Hair Growth and Its Underlying Biological Mechanism Communications biology · 2022
    2. Keratin Is Not Only a Structural Protein in Hair: Keratin-Mediated Hair Growth Research Square (Research Square) · 2020
    3. Delayed Wound Healing in Keratin 6a Knockout Mice Molecular and Cellular Biology · 2000
    4. Keratin Expression in Basal Cell Carcinomas British Journal of Dermatology · 1992