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Glossary P-cadherin

protein aiding cell adhesion in tissue structure maintenance

P-cadherin is a protein that helps cells stick together, playing a crucial role in maintaining the structure of tissues, including hair follicles. It is part of the cadherin family, which are important for cell adhesion, signaling, and maintaining the integrity of tissues. In the context of hair, abnormalities in P-cadherin expression can be linked to hair loss conditions like alopecia.

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Research

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research Topobiology of Human Pigmentation: P-Cadherin Selectively Stimulates Hair Follicle Melanogenesis

29 citations , January 2013 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this study, silencing P-cadherin in human scalp hair follicles reduced melanogenesis and associated protein expression, suggesting P-cadherin is crucial for normal hair pigmentation via GSK3β-mediated Wnt signaling.

research The role of P-cadherin in skin biology and skin pathology: lessons from the hair follicle

15 citations , February 2015 in “Cell & tissue research/Cell and tissue research”

This review examines the role of P-cadherin in skin and hair biology, emphasizing its importance in human hair growth, cycling, and pigmentation, and reports no new research findings.

research The Rho GTPase regulator ARHGEF3 orchestrates hair placode budding by coordinating cell fate and P-cadherin patterning in mice

January 2026 in “PLoS Biology”

This study used developing mouse hair follicles to explore early epithelial bud formation, finding that the Rho GTPase regulator ARHGEF3 plays a crucial role in regulating cell fate and cadherin patterning, with knockouts showing disrupted morphology and increased straight hair follicle growth.

research Dual blockage of P-cadherin and c-Met synergistically inhibits the growth of head and neck cancer

May 2025 in “Cellular Oncology”

This study suggests that dual inhibition of P-cadherin and c-Met could be an effective treatment strategy for head and neck squamous cell carcinoma by targeting resistant tumor cells.

research Novel compound heterozygous cadherin 3 mutations in hypotrichosis and juvenile macular dystrophy

1 citations , June 2022 in “Chinese medical journal/Chinese Medical Journal”

This study identified two novel mutations in the CDH3 gene causing HJMD in a Chinese patient, expanding the genetic and phenotypic understanding of the disorder.

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community Prolactin the Cause of Hair Loss? ABS-201 the Cure?

29 upvotes 2 months ago

Prolactin may contribute to hair loss, but targeting its receptor won't cure androgenetic alopecia. ABS-201 could be a useful alternative or adjuvant therapy, similar to JAK inhibitors, but not more effective than HMI-115.

community P-1075: a BETTER version of Minoxidil

11 months ago

P-1075 is a more potent hair growth agent than Minoxidil, but it poses significant heart risks, making it unsafe for use. Despite promising results in macaques, concerns about its cardiotoxicity in rats have halted its development.

community Topical finasteride (P-3074) inhibits scalp DHT up to 70%

in Finasteride/Dutasteride 20 upvotes 7 months ago

Topical finasteride (P-3074) can inhibit scalp DHT by up to 70%, with some users experiencing systemic absorption similar to oral use. Users discuss varying application frequencies and concentrations, with some noticing side effects when overused.

community How does Pedro P have a full head of hear. I'm losing mine and will be bald within 1 year. I'm not even 30yo.

643 upvotes 11 months ago

Pedro Pascal's full head of hair is likely due to genetics, finasteride, and possibly hair transplants. Many actors use finasteride to maintain their hair.

community Still losing on fin 5x & dut 2x p/w (1.5 years in) - next steps advice

1 upvotes 1 year ago

The user has been using finasteride and minoxidil for 5 years with initial success but is now experiencing hair thinning despite increasing dutasteride usage. They are considering adjusting dutasteride frequency and possibly adding treatments like eucapil, minoxidil, and GHK-Cu peptides.

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learn Transcutol P

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