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    Glossary P-cadherin

    protein aiding cell adhesion in tissue structure maintenance

    P-cadherin is a protein that helps cells stick together, playing a crucial role in maintaining the structure of tissues, including hair follicles. It is part of the cadherin family, which are important for cell adhesion, signaling, and maintaining the integrity of tissues. In the context of hair, abnormalities in P-cadherin expression can be linked to hair loss conditions like alopecia.

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    1. Topobiology of Human Pigmentation: P-Cadherin Selectively Stimulates Hair Follicle Melanogenesis 2013 · 29 citations
    2. The role of P-cadherin in skin biology and skin pathology: lessons from the hair follicle 2015 · 15 citations
    3. The Rho GTPase regulator ARHGEF3 orchestrates hair placode budding by coordinating cell fate and P-cadherin patterning in mice PLoS Biology · 2026
    4. Dual blockage of P-cadherin and c-Met synergistically inhibits the growth of head and neck cancer Cellular Oncology · 2025
    5. Novel compound heterozygous cadherin 3 mutations in hypotrichosis and juvenile macular dystrophy 2022 · 1 citations
    6. Biology and Genetics of Hair Annual Review of Genomics and Human Genetics · 2010 · 89 citations
    7. Histopathology of Hypotrichosis with Juvenile Macular Dystrophy The American Journal of Dermatopathology · 2004 · 19 citations
    8. Keratin-mediated hair growth and its underlying biological mechanism Communications biology · 2022 · 7 citations
    9. The combination of hair follicle-specific marker LHX2 and co-expressed marker can distinguish between sweat gland placodes and hair placodes in rat Journal of Molecular Histology · 2021 · 5 citations
    10. Hypotrichosis with juvenile macular dystrophy: a case report with molecular study Arquivos Brasileiros de Oftalmologia · 2017 · 5 citations
    11. Mimicking Hair Disorders by Genetic Manipulation of Organ-Cultured Human Hair Follicles Journal of Investigative Dermatology · 2012 · 5 citations
    12. Hypotrichosis with juvenile macular dystrophy International Journal of Trichology · 2018 · 4 citations
    13. Immunoexpression of Adhesion Molecules During Human Fetal Hair Development Revista Científica Hospital Santa Izabel · 2021 · 1 citations
    14. 1017 The prostaglandin F2α analog bimatoprost activates secondary hair germ cells to promote hair growth through two distinct signaling pathways Journal of Investigative Dermatology · 2026
    15. ARHGEF3 Regulates Hair Follicle Morphogenesis 2024
    16. Hypotrichosis with juvenile macular dystrophy: a case report with molecular study 2018
    17. 194 An underlying mechanism of hair loss in acrodermatitis enteropathica Journal of Investigative Dermatology · 2016
    18. Genetics of Alopecia Encyclopedia of Life Sciences · 2012
    19. Hair & Cutaneous Development Journal of Investigative Dermatology · 2012
    20. In This Issue Journal of Investigative Dermatology · 2000
    21. 361 p120-catenin regulates epidermal inflammation in a cadherin-dependent manner 2023
    22. PIEZO1-mediated calcium signaling reinforces mechanical properties of hair follicle stem cells to promote quiescence Science Advances · 2025
    23. 839 Spatiotemporal antagonism in mesenchymal-epithelial Signaling in sweat versus hair fate decision Journal of Investigative Dermatology · 2017
    24. Abstract 4350: Pharmacodynamic biomarkers: Evaluation of oncology drug target engagement in human plucked scalp and beard hair Cancer Research · 2023
    25. 876 Imaging nanoscale changes in desmosome protein organization Journal of Investigative Dermatology · 2018
    26. Recovery Effects of Oral Supplementation with Polar Lipid-Rich Wheat Extracts on Acute Telogen Effluvium: A Randomized Double-Blind Placebo-Controlled Study Clinical Cosmetic and Investigational Dermatology · 2025
    27. A desmosomal cadherin controls multipotent hair follicle stem cell quiescence and orchestrates regeneration through adhesion signaling iScience · 2023 · 1 citations
    28. Hardwiring Stem Cell Communication through Tissue Structure Cell · 2016 · 82 citations
    29. A Missense Mutation in the Cadherin Interaction Site of The Desmoglein 4 Gene Underlies Localized Autosomal Recessive Hypotrichosis Journal of Investigative Dermatology · 2005 · 33 citations
    30. Congenital hair loss disorders: Rare, but not too rare The Journal of Dermatology · 2011 · 41 citations