Human Hair Keratin and Its-Based Biomaterials for Biomedical Applications

August 2014 in “ Jo'jig gonghag gwa jaesaeng uihag/Tissue engineering and regenerative medicine ”

Hanna Lee, Kwantae Noh, Sang Cheon Lee, Il-Keun Kwon, Dong‐Wook Han, In-Seop Lee, Yu‐Shik Hwang

human hair keratin keratin hydrogels porous keratin scaffolds biocompatibility osseointegration tissue engineering drug delivery hemostatic properties

Studysummary Human hair keratin can be used in many medical applications.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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Research cited in this study

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research Hemostatic Properties and the Role of Cell Receptor Recognition in Human Hair Keratin Protein Hydrogels

118 citations , January 2013 in “Biomaterials”

This study characterized keratin-based biomaterials that self-assemble into hydrogels, demonstrating their potential to achieve hemostasis in a lethal liver injury model through specific biomaterial-receptor interactions.

research Human Keratin Hydrogels Support Fibroblast Attachment and Proliferation In Vitro

143 citations , January 2012 in “Cell and Tissue Research”

research Chemical Composition of Different Hair Types

72 citations , December 2011

research Unique Amino Acid Signatures That Are Evolutionarily Conserved Distinguish Simple-Type, Epidermal, and Hair Keratins

76 citations , December 2011 in “Journal of Cell Science”

This study found that keratins have evolutionarily conserved and domain-selectively enriched amino acids, which likely reflect their unique structural roles, with distinct patterns observed among epidermal, hair, and simple-type epithelial keratins.

research Mechanical and Biological Properties of Keratose Biomaterials

140 citations , August 2011 in “Biomaterials”

This study observed that keratose, derived from human hair, integrated well in mouse tissue and remodeled with collagen, suggesting potential as a non-toxic biomaterial for regenerative applications.

research Mechanisms of Hepatocyte Attachment to Keratin Biomaterials

53 citations , July 2011 in “Biomaterials”

This study observed that hepatocyte adhesion to human hair keratin biomaterials was mediated by the hepatic ASGPR, as blocking this receptor reduced cell attachment.

research Keratin Hydrogels Support the Sustained Release of Bioactive Ciprofloxacin

99 citations , June 2011 in “Journal of biomedical materials research. Part A”

This study observed that keratose hydrogels sustained ciprofloxacin release over three weeks and inhibited Staphylococcus aureus growth in vitro for 23 days and in mice for 2 weeks.

research Keratin Film Made of Human Hair as a Nail Plate Model for Studying Drug Permeation

68 citations , February 2011 in “European Journal of Pharmaceutics and Biopharmaceutics”

This study found that keratin films made from human hair can potentially substitute for human nail plates in drug permeability studies, but they show higher sensitivity to penetration enhancers compared to bovine hooves.

research Dlx3 Is a Crucial Regulator of Hair Follicle Differentiation and Cycling

132 citations , August 2008 in “Development”

This research found that Dlx3 plays a central role in hair formation and regeneration, with its absence leading to alopecia through disrupted differentiation and signaling pathways.

research The Human Keratins: Biology And Pathology

1398 citations , May 2008 in “Histochemistry and Cell Biology”

This review summarizes the cell type distribution and functional significance of human keratins, emphasizing their roles in tumor diagnosis and potential clinical applications, and reports no new clinical findings.

research The Use of Keratin Biomaterials Derived from Human Hair for the Promotion of Rapid Regeneration of Peripheral Nerves

309 citations , October 2007 in “Biomaterials”

This study found that a biomaterial gel made from human hair keratins facilitated nerve regeneration in an animal model, potentially matching the effectiveness of traditional autografts.

research The Hair Cycle

103 citations , January 2006 in “Journal of Cell Science”

This review summarizes the major events and regulators of the hair cycle in mammals but reports no new experimental results; it emphasizes the complex regulation of stem cell activation and differentiation during hair growth.

research Human Hair Keratin-Associated Proteins

226 citations , January 2006 in “International review of cytology”

Keratin-associated proteins are crucial for hair strength and structure.

research Characterization of the Lipid Composition at the Proximal Root Regions of Human Hair

41 citations , May 2005 in “International Journal of Cosmetic Science”

This study observed that in Japanese females, hair lipid composition showed significant correlations, suggesting CH and CERs may act as a barrier against sebum-derived lipids.

research Keratin 16 Expression Defines a Subset of Epithelial Cells During Skin Morphogenesis and the Hair Cycle

87 citations , November 2002 in “Journal of Investigative Dermatology”

research Hard and Soft Principles Defining the Structure, Function, and Regulation of Keratin Intermediate Filaments

686 citations , February 2002 in “Current Opinion in Cell Biology”

Keratin filaments are crucial for cell structure and protection, with ongoing discoveries about their genes and functions.

research Bone Morphogenetic Protein-2 Transactivates Dlx3 Through Smad1 and Smad4: Alternative Mode for Dlx3 Induction in Mouse Keratinocytes

79 citations , January 2002 in “Nucleic Acids Research”

This study found that BMP-2 activates Dlx3 gene transcription in murine keratinocytes by binding with Smad1/Smad4, suggesting a mechanism for BMP signaling's role in skin and hair follicle regulation.

research A Rapid Extraction Procedure of Human Hair Proteins and Identification of Phosphorylated Species

226 citations , January 2002 in “Biological and Pharmaceutical Bulletin”

This study developed a rapid method to extract proteins from human hair, revealing phosphorylation on serine and threonine residues in alpha-keratins and matrix proteins.

research Human Hair Keratins

38 citations , July 1993 in “Journal of Investigative Dermatology”

research Expression of Hair-Related Keratins in a Soft Epithelium: Subpopulations of Human and Mouse Dorsal Tongue Keratinocytes Express Keratin Markers for Hair, Skin, and Esophageal Types of Differentiation

128 citations , March 1989 in “Experimental Cell Research”

Hoxc13 is important for hair and tongue development by controlling hair keratin genes.

research Patterns of Expression of Trichocytic and Epithelial Cytokeratins in Mammalian Tissues: Human and Bovine Hair Follicles

248 citations , April 1988 in “Differentiation”

In this study, researchers observed that trichocytic and epithelial cytokeratins have distinct expression patterns within various human and bovine hair follicle cells, contributing to understanding hair follicle development and growth.

Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins

research Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins

356 citations , December 1986 in “The journal of cell biology/The Journal of cell biology”

This study found that specific human hair keratins are differentially expressed in the hair follicle, suggesting a shared pathway of epithelial differentiation between hair cortex and nail plate cells.