Keratin Film Made of Human Hair as a Nail Plate Model for Studying Drug Permeation
February 2011
in “
European Journal of Pharmaceutics and Biopharmaceutics
”
New to Keratin? There is a guide in the encyclopedia. Read the guide → Studysummary This study found that keratin films made from human hair can potentially substitute for human nail plates in drug permeability studies, but they show higher sensitivity to penetration enhancers compared to bovine hooves. Our plain-language summary of this paper — not a Tressless recommendation.
The study developed a keratin film from human hair as a substitute for human nail plates to study drug permeation. The film demonstrated mechanical stability and water resistance, making it suitable for permeation experiments. It showed similar permeability to bovine hooves, particularly for hydrophilic substances, suggesting its potential as a human nail plate model. However, the use of lipophilic drugs and penetration enhancers required careful interpretation.
