TLDR Keratin films from human hair can potentially replace human nail plates for drug testing.
The study developed a keratin film from human hair as a substitute for human nail plates to study drug permeation. The film demonstrated mechanical stability and water resistance, making it suitable for permeation experiments. It showed similar permeability to bovine hooves, particularly for hydrophilic substances, suggesting its potential as a human nail plate model. However, the use of lipophilic drugs and penetration enhancers required careful interpretation.
150 citations,
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Keratin hydrogels from human hair show promise for tissue engineering and regenerative medicine.
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