Keratin Film Made of Human Hair as a Nail Plate Model for Studying Drug Permeation

    February 2011 in “ European Journal of Pharmaceutics and Biopharmaceutics ”
    Lusiana Lusiana, Stephan Reichl, Christel C. Müller‐Goymann
    Studysummary This study found that keratin films made from human hair can potentially substitute for human nail plates in drug permeability studies, but they show higher sensitivity to penetration enhancers compared to bovine hooves.
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    Research cited in this study 5

    1. A Rapid Extraction Procedure of Human Hair Proteins and Identification of Phosphorylated Species Biological and Pharmaceutical Bulletin · 2002
    2. Hair Care Products: Waving, Straightening, Conditioning, and Coloring Clinics in dermatology · 2001
    3. Variation of Differentiation in Nail and Bovine Hoof Cells Journal of Investigative Dermatology · 1994
    4. The Extraction And Characterization Of Human Nail Keratin Journal of Dermatological Science · 1991
    5. Permanent Waving and Hair Straightening Clinics in dermatology · 1988