TLDR Phospholipid soft vesicles improve topical drug delivery for better skin condition treatments.
The review discussed the use of phospholipid soft vesicles, such as ethosomes and glycerosomes, for enhancing topical drug delivery in treating various skin conditions, including acne, infections, inflammation, psoriasis, skin cancer, and hair loss. These vesicles improved drug penetration and efficacy by fluidizing the lipid bilayers of the stratum corneum. Notable findings included ethosomal gels showing significant improvement in acne symptoms in a clinical trial with 40 patients, ethosomes enhancing antiviral effects against herpes simplex virus, and ethosomal systems improving drug delivery for skin cancer and hair loss treatments. For hair loss, minoxidil ethosomes demonstrated higher skin permeation and follicle targeting. Overall, these vesicular carriers showed potential for improving drug delivery and therapeutic outcomes in skin-related medical conditions.
16 citations
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July 2020 in “Advances in Traditional Medicine” The combined herbal extract formulation promotes hair growth safely without skin irritation.
222 citations
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January 2003 in “Critical Reviews in Therapeutic Drug Carrier Systems” Ethosomes can safely and effectively deliver various drugs deep into the skin.
72 citations
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January 2001 in “Drugs” Minoxidil and finasteride treat hair loss; more research needed for other options.
370 citations
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September 1999 in “The New England Journal of Medicine” Finasteride and minoxidil are effective for hair loss, but continued research is needed for better treatments.
1 citations
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February 2024 in “Pharmaceutics” Nanovesicles improve drug delivery through the skin, offering better treatment outcomes and fewer side effects.
222 citations
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January 2003 in “Critical Reviews in Therapeutic Drug Carrier Systems” Ethosomes can safely and effectively deliver various drugs deep into the skin.
21 citations
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July 2017 in “Journal of Cosmetic and Laser Therapy” Vesicular carriers like liposomes may improve cosmetic skin treatment delivery and effectiveness but need more human research.
13 citations
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October 2023 in “Pharmaceutics” The new nasal gel for schizophrenia improved drug absorption and brain effects in rats.
151 citations
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July 2011 in “Archives of Dermatological Research” Liposomal systems show promise for delivering drugs through the skin but face challenges like high costs and stability issues.
