Human Hair Keratin Hydrogel: Fabrication, Characterization, and Application

January 2014

Shuai Wang

Studysummary This research found that keratin hydrogels derived from human hair may support cell viability and proliferation, indicating potential as 2D and 3D soft tissue culture scaffolds.

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Research cited in this study

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research In Vitro Assembly Properties of Human Type I and II Hair Keratins

1 citations , January 2014 in “Medical Entomology and Zoology”

research The Human Hair: From Anatomy to Physiology

107 citations , December 2013 in “International Journal of Dermatology”

This review summarizes the anatomical and physiological aspects of human hair and its clinical significance, but does not report new research findings.

research The Effect of Human Hair Keratin Hydrogel on Early Cellular Response to Sciatic Nerve Injury in a Rat Model

105 citations , May 2013 in “Biomaterials”

In this study, the researchers found that a keratin hydrogel filler in nerve conduits led to earlier Schwann cell migration and improved cellular behaviors compared to other fillers in a rat sciatic nerve model.

research Hemostatic Properties and the Role of Cell Receptor Recognition in Human Hair Keratin Protein Hydrogels

118 citations , January 2013 in “Biomaterials”

This study characterized keratin-based biomaterials that self-assemble into hydrogels, demonstrating their potential to achieve hemostasis in a lethal liver injury model through specific biomaterial-receptor interactions.

research Understanding the Nanotopography Changes and Cellular Influences Resulting from the Surface Adsorption of Human Hair Keratins

41 citations , May 2012 in “Advanced Healthcare Materials”

This study found that human hair keratin coatings enhanced adhesion and proliferation of L929 mouse fibroblasts compared to uncoated and collagen type 1 surfaces, suggesting keratin's potential as a surface coating for cell cultures.

research Human Keratin Hydrogels Support Fibroblast Attachment and Proliferation In Vitro

143 citations , January 2012 in “Cell and Tissue Research”

research Structure–Property Relationships of Meta-Kerateine Biomaterials Derived from Human Hair

47 citations , September 2011 in “Acta biomaterialia”

This study observed that increasing the γ-kerateine content in meta-kerateine materials led to reduced elasticity, solidity, and hydrolytic stability, and decreased hepatocyte attachment support.

research Mechanical and Biological Properties of Keratose Biomaterials

140 citations , August 2011 in “Biomaterials”

This study observed that keratose, derived from human hair, integrated well in mouse tissue and remodeled with collagen, suggesting potential as a non-toxic biomaterial for regenerative applications.

research Mechanisms of Hepatocyte Attachment to Keratin Biomaterials

53 citations , July 2011 in “Biomaterials”

This study observed that hepatocyte adhesion to human hair keratin biomaterials was mediated by the hepatic ASGPR, as blocking this receptor reduced cell attachment.

research Keratin Film Made of Human Hair as a Nail Plate Model for Studying Drug Permeation

68 citations , February 2011 in “European Journal of Pharmaceutics and Biopharmaceutics”

This study found that keratin films made from human hair can potentially substitute for human nail plates in drug permeability studies, but they show higher sensitivity to penetration enhancers compared to bovine hooves.

research A Review of Keratin-Based Biomaterials for Biomedical Applications

517 citations , February 2010 in “Materials”

This review discusses the history and development of keratin biomaterials for biomedical uses, highlighting their biological activity and biocompatibility, and provides no new research findings.

research Preparation of Scaffolds from Human Hair Proteins for Tissue-Engineering Applications

177 citations , April 2008 in “Biomedical Materials”

This study found that scaffolds made from human hair proteins supported better cell growth and interactions than control surfaces, indicating potential use in tissue engineering.

research In Situ Tensile Deformation Characterization of Human Hair with Atomic Force Microscopy

81 citations , December 2007 in “Acta materialia”

This study conducted in situ tensile loading experiments with atomic force microscopy to observe how conditioning treatments affect the tensile response of virgin, chemically damaged, and mechanically damaged Caucasian hair.

research Novel Type I Hair Keratins K39 And K40 Are The Last To Be Expressed In Differentiation Of The Hair: Completion Of The Human Hair Keratin Catalog

70 citations , February 2007 in “Journal of Investigative Dermatology”

K39 and K40 are the last keratins expressed in hair development, completing the hair keratin catalog.

research Structural Changes in Trichocyte Intermediate Filaments During Transition from Reduced to Oxidized Form

31 citations , February 2007 in “Journal of Structural Biology”

Oxidation changes the structure of hair protein filaments, causing them to compact and rearrange.

research Nucleation and Growth of Macrofibrils in Trichocyte (Hard-Alpha) Keratins

24 citations , June 2003 in “Journal of Structural Biology”

This study suggests that varying intersheet interactions may explain the differences between the two polymorphic forms of macrofibril assembly in Merino wool and hair.

research Human Hair: A Unique Physicochemical Composite

203 citations , June 2003 in “Journal of the American Academy of Dermatology”

This article reviews the structure and chemistry of hair across ethnicities and how these factors affect hair properties and treatment responses, but reports no new research findings.

research Hard and Soft Principles Defining the Structure, Function, and Regulation of Keratin Intermediate Filaments

686 citations , February 2002 in “Current Opinion in Cell Biology”

Keratin filaments are crucial for cell structure and protection, with ongoing discoveries about their genes and functions.

research A Rapid Extraction Procedure of Human Hair Proteins and Identification of Phosphorylated Species

226 citations , January 2002 in “Biological and Pharmaceutical Bulletin”

This study developed a rapid method to extract proteins from human hair, revealing phosphorylation on serine and threonine residues in alpha-keratins and matrix proteins.

research The Catalog of Human Hair Keratins

272 citations , September 2001 in “Journal of Biological Chemistry”

This study cataloged human type II hair keratins, detailing their expression and differentiation roles in hair follicles and comparing them with type I keratins to explore keratin-pairing principles.

research In Vitro Assembly and Structure of Trichocyte Keratin Intermediate Filaments

91 citations , December 2000 in “The journal of cell biology/The Journal of cell biology”

This study reports that expressed mouse type Ia and type IIa trichocyte keratins were successfully assembled into intermediate filaments in vitro, while also suggesting that disulfide bond cross linking enhances their stability.

research The Catalog of Human Hair Keratins

235 citations , July 1999 in “Journal of biological chemistry/The Journal of biological chemistry”

This study establishes a catalog of human type I hair keratins and identifies their specific roles and expression patterns during hair differentiation and growth in scalp follicles.