Bone Morphogenetic Protein-2 Transactivates Dlx3 Through Smad1 and Smad4: Alternative Mode for Dlx3 Induction in Mouse Keratinocytes

    January 2002 in “ Nucleic Acids Research ”
    G. T. Park
    TLDR BMP-2 activates the Dlx3 gene in mouse skin cells, important for hair and skin development.
    The study explored how Bone Morphogenetic Protein-2 (BMP-2) regulated the Dlx3 gene in mouse keratinocytes and hair follicle cells. BMP-2 was shown to induce Dlx3 transcription within 12 hours by binding Smad1 and Smad4 to a specific GCAT sequence in the Dlx3 promoter. This mechanism was independent of the keratinocytes' differentiation state and provided an alternative to the known PKC-dependent Ca2+ activation pathway. The findings emphasized the role of BMP signaling in Dlx3 expression, crucial for hair follicle development and epidermal differentiation.
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