TLDR The PLP2 gene affects cashmere fiber quality in goats and is linked to hair growth and loss.
The study investigated the role of the PLP2 gene in the quality of cashmere fiber in Liaoning cashmere goats. It was found that the PLP2 gene expression is higher during the prosperous and degenerative stages of hair growth compared to the primary follicle, suggesting that PLP2 promotes secondary follicle development. The gene is specifically expressed in the inner root sheath, which may link it to hair loss. RT-PCR results indicated that FGF5 expression is positively regulated by the PLP2 gene, while melatonin (MT) negatively regulates PLP2 expression, with increased inhibition over time. Additionally, the study confirmed that the Noggin gene, an inhibitor of the BMP signaling pathway, downregulates PLP2 expression when interfered with by lentivirus infection. This suggests that PLP2, along with other suppressor genes like Noggin, may influence hair follicle development by inhibiting the BMP pathway.
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