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GlossaryFibroblast Growth Factor 5 (FGF5)

protein that inhibits hair growth by signaling phase transition

Fibroblast Growth Factor 5 (FGF5) is a protein that plays a crucial role in regulating the hair growth cycle. Specifically, it acts to inhibit hair growth by signaling the transition from the growth phase (anagen) to the regression phase (catagen), which can lead to shorter hair growth periods and potentially contribute to conditions like alopecia.

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research FGF5 Is a Crucial Regulator of Hair Length in Humans

136 citations, July 2014 in “Proceedings of the National Academy of Sciences of the United States of America”

FGF5 gene mutations cause unusually long eyelashes by affecting hair growth regulation.

research Characterization of Hairless (Hr) and FGF5 Genes Provides Insights into the Molecular Basis of Hair Loss in Cetaceans

50 citations, February 2013 in “BMC evolutionary biology”

Cetaceans lost hair due to changes in the Hr and FGF5 genes.

research CRISPR/Cas9-Mediated Loss of FGF5 Function Increases Wool Staple Length in Sheep

47 citations, June 2017 in “The FEBS journal”

Disabling the FGF5 gene in sheep leads to longer wool.

Fibroblast Growth Factor 5-Short (FGF5s) Inhibits the Activity of FGF5 in Primary and Secondary Hair Follicle Dermal Papilla Cells of Cashmere Goats

research Fibroblast Growth Factor 5-Short (FGF5s) Inhibits the Activity of FGF5 in Primary and Secondary Hair Follicle Dermal Papilla Cells of Cashmere Goats

42 citations, September 2015 in “Gene”

FGF5s can block the effects of FGF5, which may help control hair growth in cashmere goats.

Promotion of Anagen, Increased Hair Density, and Reduction of Hair Fall in a Clinical Setting Following Identification of FGF5-Inhibiting Compounds via a Novel 2-Stage Process

research Promotion of Anagen, Increased Hair Density, and Reduction of Hair Fall in a Clinical Setting Following Identification of FGF5-Inhibiting Compounds via a Novel 2-Stage Process

27 citations, February 2017 in “Clinical, Cosmetic and Investigational Dermatology”

New compounds were found to help increase hair growth and decrease hair loss.

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community Mystery compound found to be safe and effective at treating hair loss. Details in comments.

in Technology 6 upvotes 5 years ago

A compound called MTP3 from the Monoterpene family was found to be safe and highly effective at treating hair loss by inhibiting the FGF5 gene, but its identity is undisclosed for commercial reasons. No specific treatments like Minoxidil, finasteride, or RU58841 were discussed.

community DIY treatment... Shedding completely stopped after 1.5 yrs

in Treatment 249 upvotes 2 years ago

Vitamin C mixed with shampoo stopped shedding and promoted hair regrowth after 1.5 years. Both the person and their wife experienced significant hair loss reduction with this method.

community Sanguisorba Officinalis Root Extract, and other FGF-5 inhibitors?

in Question 4 upvotes 7 years ago

The conversation discusses the potential of Sanguisorba Officinalis Root Extract as a treatment for hair loss by inhibiting FGF-5. The user also mentions the product évolis, which is based on this extract but is only available in the US and Australia.