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research The Noggin null mouse phenotype is strain dependent and haploinsufficiency leads to skeletal defects

49 citations , January 2006 in “Developmental Dynamics”

This research observed that the skeletal abnormalities in Noggin null mice varied based on genetic background, and identified haploinsufficiency leading to joint fusions, similar to human conditions associated with NOGGIN deficiency.

research Expression of lipid-protein gene PLP2 in Liaoning cashmere goat

3 citations , February 2019 in “Animal biotechnology”

In this study, the PLP2 gene was found to promote secondary hair follicle development in Liaoning cashmere goats, with its expression negatively regulated by melatonin and potentially affecting follicle development via the BMP pathway.

research Shh maintains dermal papilla identity and hair morphogenesis via a Noggin–Shh regulatory loop

138 citations , June 2012 in “Genes & Development”

This study found that dermal Shh signaling regulates specific dermal papilla signatures essential for maintaining hair follicle development, suggesting that the Shh-Noggin signaling loop is crucial for hair morphogenesis.

research Bone morphogenetic protein signaling regulates the size of hair follicles and modulates the expression of cell cycle-associated genes

92 citations , November 2006 in “Proceedings of the National Academy of Sciences of the United States of America”

This study found that transgenic mice overexpressing the BMP antagonist noggin showed increased hair follicle size and altered hair type, linked to changes in cell proliferation and gene expression.

research CRISPR/Cas9-mediatedVDRknockout plays an essential role in the growth of dermal papilla cells through enhanced relative genes

2 citations , July 2019 in “PeerJ”

This study found that the vitamin D receptor plays a crucial role in hair follicle development in cashmere goats by regulating signaling pathways in dermal papilla cells.

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Community Join

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community What's your option on complementary treatment

3 upvotes 2 years ago

The conversation discusses complementary treatments for hair loss while using finasteride and minoxidil, including scalp massagers, scrubs, coconut oil, and vitamin supplements. The user seeks opinions on these additional treatments.

community Here are the steps I'm taking in my hair regrowth journey!

4 upvotes 6 months ago

A user shares their hair regrowth journey using finasteride and minoxidil, highlighting lifestyle changes to enhance results. Another user reports negative side effects from finasteride and plans to try ketoconazole shampoo and natural oils.

community Do people still use microneedling?

in Treatment 10 upvotes 11 months ago

Microneedling is still considered effective for hair growth, especially when combined with minoxidil, though it is time-consuming. Some users report significant success with consistent use, while others find it less popular due to the effort required compared to topical treatments alone.

community BREAKTHROUGH: I’m a radiochemist and discovered a radioactive isotope scalp serum that OUTPERFORMS Minoxidil and 5-AR inhibitors! (Lab Data Inside)

in Satire 1 year ago

A satirical post where someone claims to have developed a radioactive isotope scalp serum using Polonium-210 that outperforms Minoxidil and finasteride for hair regrowth. The serum reportedly stimulates DNA repair in hair follicles, leading to significant hair density increase, but the post is met with skepticism and concerns about safety.

community Hospital stay loss of gains. Pic 1 - 2020 start on Fin/min, pic 2 - July 2024 gains, pic 3 - today, 3 months after no fin/min hospital.

in Progress Pictures 594 upvotes 1 year ago

Stopping finasteride and minoxidil during a hospital stay led to significant hair loss. Resuming the treatment is expected to restore hair growth.

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Clinics

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18
SMP
Noggin Master StudiosPittsburgh, PA · US

Experts

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21
Hair System Specialist
Jane Genesi
Marlton, PA, United States

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Jane Genesi