Effect of Tofacitinib on the Expression of Noggin/BMP-4 and Hair Growth Stimulation in Mice

October 2018 in “ Archives of Dermatological Research ”

Jitlada Meephansan, Thanet Pongcharoensuk, J. Thummakriengkrai, Saranyoo Ponnikorn, Werayut Yingmema, Raksawan Deenonpoe

tofacitinib noggin BMP4 hair growth anagen phase hair follicles interfollicular epidermis RT-PCR minoxidil Xeljanz bone morphogenetic protein 4 Rogaine

TLDR Tofacitinib helps mice grow more hair by increasing noggin and BMP4 levels, possibly better than minoxidil.

The study from October 5, 2018, examined the effects of topical tofacitinib on hair growth in 14 male C57BL/6 mice over 21 days, comparing seven treated with tofacitinib to seven treated with DMSO as a control. The results indicated that tofacitinib-treated mice exhibited a greater number of hair follicles in the anagen phase, longer hair infundibulum, and thinner interfollicular epidermis. RT-PCR analysis showed significant increases in noggin and BMP4 mRNA expressions in the tofacitinib group compared to controls and minoxidil-treated groups. The study concluded that tofacitinib promotes hair growth by upregulating noggin and BMP4, potentially offering a superior treatment mechanism for hair loss disorders than minoxidil.

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Research cited in this study

7 / 7 results

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research Bone Morphogenetic Proteins and Their Antagonists in Skin and Hair Follicle Biology

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research Noggin Is Required for Induction of the Hair Follicle Growth Phase in Postnatal Skin

211 citations, October 2001 in “The FASEB Journal”

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Related Research

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research Adipose Mesenchymal Stromal Cell-Derived Exosomes Carrying MiR-122-5p Antagonize the Inhibitory Effect of Dihydrotestosterone on Hair Follicles by Targeting the TGF-β1/SMAD3 Signaling Pathway

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ADSC-Exos with miR-122-5p can help treat hair loss by promoting hair growth.

Case Report: Successful Treatment of Alopecia Universalis With Tofacitinib and Increased Cytokine Levels: Normal Therapeutic Reaction or Danger Signal?

research Case Report: Successful Treatment of Alopecia Universalis With Tofacitinib and Increased Cytokine Levels: Normal Therapeutic Reaction or Danger Signal?

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Efficacy of Systemic Minoxidil and Tofacitinib Combination in Treatment-Resistant Alopecia Universalis

Effect of Tofacitinib on the Expression of Noggin/BMP-4 and Hair Growth Stimulation in Mice

Research cited in this study

research Efficacy of Topical Tofacitinib in Promoting Hair Growth in Non-Scarring Alopecia: Possible Mechanism via VEGF Induction

research Safety and Efficacy of the JAK Inhibitor Tofacitinib Citrate in Patients with Alopecia Areata

research Effects of Imiquimod on Hair Follicle Stem Cells and Hair Cycle Progression

research Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth

research Shh Maintains Dermal Papilla Identity and Hair Morphogenesis via a Noggin–Shh Regulatory Loop

research Bone Morphogenetic Proteins and Their Antagonists in Skin and Hair Follicle Biology

research Noggin Is Required for Induction of the Hair Follicle Growth Phase in Postnatal Skin

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