Efficacy of Topical Tofacitinib in Promoting Hair Growth in Non-Scarring Alopecia: Possible Mechanism via VEGF Induction

    September 2017 in “ Archives of Dermatological Research ”
    Jitlada Meephansan, J. Thummakriengkrai, Saranyoo Ponnikorn, Werayut Yingmema, Raksawan Deenonpoe, Poonkiat Suchonwanit
    Image of study
    TLDR Topical tofacitinib may grow hair better than minoxidil by increasing VEGF and reducing inflammation.
    In a study from September 7, 2017, researchers found that topical tofacitinib, a JAK3 inhibitor, was effective in promoting hair growth in non-scarring alopecia in male C57BL/6 mice. The study involved 28 mice divided into four groups, each treated with tofacitinib, minoxidil, or a control vehicle daily for 21 days. Tofacitinib-treated mice exhibited significantly more and faster hair regrowth compared to those treated with minoxidil or control, with regrowth starting as early as day 7. Histological analysis showed an increased number of hair follicles in the anagen phase and higher VEGF mRNA and protein expression levels in the tofacitinib group, suggesting a mechanism involving VEGF induction and reduced inflammation. The study concluded that tofacitinib could be a more effective treatment for hair growth than minoxidil, warranting further investigation into its long-term effects and safety.
    Discuss this study in the Community →

    Research cited in this study

    21 / 21 results

    Related Community Posts Join

    6 / 11 results

      community IGE Hair Loss and Miniaturization

      in Chat  3 upvotes 4 months ago
      A 23-year-old male is experiencing diffuse hair loss and miniaturization, possibly due to high IGE levels after using tofacitinib. He seeks advice and has not yet consulted a dermatologist.

      community Topical solution recommendation

      in Treatment  1 upvotes 3 weeks ago
      The user is using finasteride 1mg every other day and seeks a topical solution excluding minoxidil. They are considering various combinations of ingredients like finasteride, dutasteride, and tofacitinib, with options for nourishing oils and other additives.

      community Topical solution recommendation

      in Product  1 upvotes 3 weeks ago
      The user is using finasteride 1mg every other day and seeks a topical solution to complement it, excluding minoxidil. They are considering various combinations of ingredients like finasteride, dutasteride, and tofacitinib, with options for nourishing oils and other additives.

      community 22F. Should I even bother getting a biopsy? Is there any point?

       6 upvotes 9 years ago
      A woman who has been experiencing hair loss for several years, and her question of whether there is any benefit to getting a biopsy to check if it's AGA or diffuse alopecia areata when no cure or very effective treatment exists. Treatments such as spironolactone and Minoxidil/finasteride/RU58841 have previously been discussed.

      community No hair, don't care! [24/F] :)

       61 upvotes 9 years ago
      A woman with alopecia universalis shares her positive experience of being bald, finding it freeing and less worrisome. She also discusses her skincare routine using Korean products.

    Related Research

    8 / 8 results