The Direct Inhibitory Effect of Dutasteride or Finasteride on Androgen Receptor Activity Is Cell Line Specific

October 2013 in “ The Prostate ”

Rishi Raj Chhipa, Danny Halim, Jinrong Cheng, Huan-yi Zhang, James L. Mohler, Clement Ip, Yue Wu

dutasteride finasteride androgen receptor AR activity AR genotype Propecia Avodart

TLDR Dutasteride and finasteride affect different cell types differently.

The study found that the inhibitory effect of dutasteride or finasteride on androgen receptor (AR) activity is cell line specific, meaning that the drugs have different effects on different types of cells. The study also found that the AR genotype does not play a significant role in determining the AR antagonistic effect of either drug. The study suggests that further research is needed to understand the role of the direct inhibitory effect of dutasteride or finasteride in reducing prostate cancer.

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Research cited in this study

3 / 3 results

research The Antiandrogenic Effect of Finasteride Against a Mutant Androgen Receptor

20 citations, May 2011 in “Cancer Biology & Therapy”

Finasteride may improve prostate cancer treatment outcomes.

research Saturable Binding of Finasteride to Steroid 5α-Reductase as Determinant of Nonlinear Pharmacokinetics

16 citations, January 2010 in “Drug Metabolism and Pharmacokinetics”

Finasteride's effect on hair loss and prostate enlargement depends on its binding to an enzyme, with maximum impact at 0.2 mg dose.

research Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor

408 citations, May 2004 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

Dutasteride more effectively lowers DHT levels in men with enlarged prostates than finasteride.

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Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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To minimize hair loss while using steroids, use finasteride or dutasteride and apply topical anti-androgens like RU58841. Avoid high doses of hair-toxic steroids; prefer testosterone, nandrolone, and boldenone.

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research The Direct Inhibitory Effect of Dutasteride or Finasteride on Androgen Receptor Activity Is Cell Line Specific

12 citations, October 2013 in “The Prostate”

Dutasteride and finasteride affect different cell types differently.

research The Antiandrogenic Effect of Finasteride Against a Mutant Androgen Receptor

20 citations, May 2011 in “Cancer Biology & Therapy”

Finasteride may improve prostate cancer treatment outcomes.