The Direct Inhibitory Effect of Dutasteride or Finasteride on Androgen Receptor Activity Is Cell Line Specific

October 2013 in “ The Prostate ”

Rishi Raj Chhipa, Danny Halim, Jinrong Cheng, Huan-yi Zhang, James L. Mohler, Clement Ip, Yue Wu

dutasteride finasteride androgen receptor AR activity AR genotype Propecia Avodart

TLDR Dutasteride and finasteride affect different cell types differently.

The study found that the inhibitory effect of dutasteride or finasteride on androgen receptor (AR) activity is cell line specific, meaning that the drugs have different effects on different types of cells. The study also found that the AR genotype does not play a significant role in determining the AR antagonistic effect of either drug. The study suggests that further research is needed to understand the role of the direct inhibitory effect of dutasteride or finasteride in reducing prostate cancer.

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Research cited in this study

3 / 3 results

research The Antiandrogenic Effect of Finasteride Against a Mutant Androgen Receptor

20 citations, May 2011 in “Cancer Biology & Therapy”

Finasteride may improve prostate cancer treatment outcomes.

research Saturable Binding of Finasteride to Steroid 5α-Reductase as Determinant of Nonlinear Pharmacokinetics

16 citations, January 2010 in “Drug Metabolism and Pharmacokinetics”

Finasteride's effect on hair loss and prostate enlargement depends on its binding to an enzyme, with maximum impact at 0.2 mg dose.

research Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor

408 citations, May 2004 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

Dutasteride more effectively lowers DHT levels in men with enlarged prostates than finasteride.

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community Dutasteride: More Than a DHT Reducer – A Potential Androgen Receptor Inhibitor?

in Finasteride/Dutasteride 30 upvotes 1 day ago

Dutasteride may inhibit androgen receptors in addition to reducing DHT, potentially explaining its effectiveness over finasteride for hair loss. Concerns about its impact on muscle growth are debated, with some suggesting no significant effects.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community One year anti androgen update CROWN

in Finasteride/Dutasteride 339 upvotes 1 year ago

User used Finasteride, Dutasteride, and Minoxidil for one year to treat hair loss. They discussed possibly trying RU58841 or pyrilutamide in the future.

community to all people who cannot tolerate anti androgens (loe dose topical fin, pyrilutamide, CB) i am getting desperate, looking for a solution

in Research/Science 13 upvotes 1 year ago

The user tried Minoxidil without success, and Finasteride worked but caused sexual side effects even at a very low dose. They are seeking alternative treatments for hair loss as they cannot tolerate anti-androgens and are also in therapy for mental health.

community PYRILUTAMIDE PHASE 3 RESULTS : No statistical significance

in Research/Science 122 upvotes 1 year ago

The phase 3 trial results for Pyrilutamide showed no significant difference from the control treatment in increasing hair count, leading to the company halting its development. Users discussed their disappointment and skepticism about hair loss treatments, with some mentioning other treatments like Minoxidil, Finasteride, and RU58841.

community How to Keep Your Hair on Steroids

in Treatment 19 upvotes 3 months ago

To minimize hair loss while using steroids, use finasteride or dutasteride and apply topical anti-androgens like RU58841. Avoid high doses of hair-toxic steroids; prefer testosterone, nandrolone, and boldenone.

Related Research

2 / 2 results

research The Direct Inhibitory Effect of Dutasteride or Finasteride on Androgen Receptor Activity Is Cell Line Specific

12 citations, October 2013 in “The Prostate”

Dutasteride and finasteride affect different cell types differently.

research The Antiandrogenic Effect of Finasteride Against a Mutant Androgen Receptor

20 citations, May 2011 in “Cancer Biology & Therapy”

Finasteride may improve prostate cancer treatment outcomes.