Is there any role for topical DHT antagonists, or does a 5-AR inhibitor remove the need for them as therapy
    1/6/2025

    From the encyclopedia
    Finasteride →

    Popular 5-alpha reductase inhibitor that lowers DHT, taken as a pill or used topically

    Dutasteride →

    5-alpha reductase inhibitor that blocks both enzyme types, a stronger DHT blocker than finasteride

    Fluridil →

    Topical anti-androgen sold as a cosmetic lotion

    At a glance
    In this question or advice post, the primary subjects mentioned are
    💊 Finasteride (oral)
    💊 Dutasteride (oral)
    💧 Topilutamide (topical)
    💧 Clascoterone (topical)
    💧 Bicalutamide (topical)
    💧 Ketoconazole (topical)
    the tone is 😐 neutral.

    Other terms

    Topical androgen receptor antagonists may not be necessary if 5-AR inhibitors like finasteride or dutasteride effectively reduce DHT levels. Combining a 5-AR inhibitor with a topical androgen antagonist could potentially enhance treatment, but oral use of androgen antagonists is too risky due to severe side effects.
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