Pathogenic Mechanisms And Mechanism-Directed Therapies For Androgenetic Alopecia: Current Understanding And Future Directions
January 2025
in “
Dermatologic Therapy
”
androgenetic alopecia dihydrotestosterone prostaglandin D2 DHT–PGD2 loop oxidative stress inflammation lipid metabolism dysregulation Wnt/β‐catenin signaling CXXC5 GSK‐3β scalp microbiome PPARγ signaling adipocyte‐follicle interactions DP2 antagonists CXXC5/GSK‐3β inhibitors antioxidants microbiome modulators PPARγ agonists AGA DHT PGD2 PPAR gamma
Studysummary In this review, researchers explored key mechanisms underlying androgenetic alopecia, revealing how hormonal, oxidative, inflammatory, and lipid dysregulation suppress hair growth pathways and suggesting new therapeutic targets such as DP2 antagonists and microbiome modulators.
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