Oxidative Stress in Androgenetic Alopecia

March 2017 in “ PubMed ”

BE Prie, Liviu Iosif, Ioan Tivig, Irina Stoian, Calin Giurcaneanu

androgenetic alopecia oxidative stress total antioxidant activity TEAC malondialdehyde MDA superoxide dismutase SOD androgenic alopecia antioxidant activity antioxidants

Studysummary In this study, patients with androgenetic alopecia showed significantly decreased antioxidant activity and increased oxidative stress markers, suggesting a role for oxidative stress in the condition.

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The 2015 study "Oxidative stress in androgenetic alopecia" involved 27 patients with androgenetic alopecia and 25 controls. The research found that patients with androgenetic alopecia, a common form of hair loss, showed signs of increased oxidative stress, indicated by decreased total antioxidant activity (TEAC) and increased malondialdehyde (MDA) levels in the plasma. However, no significant change was found in the activity of other antioxidant systems in the erythrocytes (red blood cells) of these patients, suggesting a compensatory mechanism for decreased superoxide dismutase (SOD) activity. The study suggested that therapies aimed at reducing oxidative stress could be beneficial in treating this type of hair loss, but more research is needed to fully understand the mechanisms involved and to develop effective treatments.

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