Development of Tea Seed Oil Nanostructured Lipid Carriers and In Vitro Studies on Their Applications in Inducing Human Hair Growth

May 2022 in “ Pharmaceutics ”

Pornthida Riangjanapatee, Mattaka Khongkow, Alongkot Treetong, Onuma Unger, Chutikorn Phungbun, Supatchaya Jaemsai, Chatchaya Bootsiri, Siriporn Okonogi

nanostructured lipid carriers tea seed oil Tween 80 Varisoft 442 human follicle dermal papilla cells hair serum NLC HFDP cells

TLDR Tea seed oil in nanostructured carriers stimulates hair growth and feels less greasy when applied.

The study developed and tested nanostructured lipid carriers (NLC) loaded with tea seed oil for their potential to stimulate human hair growth. Three types of NLC were created using different surfactants, with the combination of Tween 80 and Varisoft 442 (NLC-C) showing the greatest non-toxicity and growth-stimulating effect on human follicle dermal papilla (HFDP) cells. The NLC-C had a melting point of 52 ± 0.02 °C and an entrapment efficiency of 96.26 ± 2.26%. A hair serum containing NLC-C showed better spreading and reduced firmness by 78.8%, enhancing diffusion efficiency by reducing shear forces up to 81.4%. The study concluded that NLC-C of tea seed oil effectively stimulates hair growth and reduces the sticky, oily, and greasy feeling after use.

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