GC-MS Profiling and In Silico Prediction of MAPK Receptor Activation by Fatty Acids of Watercress Oil for Hair Growth Marketed in Saudi Arabia

January 2021 in “ Journal of Saudi Chemical Society ”

Mohammed Al Bratty, Hassan A. Alhazmi, Neelaveni Thangavel

watercress oil GC-MS in-silico methods fatty acids oleic acid palmitic acid MAPK1 MAPK3 MAPKp38 hair growth regulation molecular docking WCO gas chromatography-mass spectrometry computer simulation methods hair growth

TLDR Watercress oil may promote hair growth by activating specific receptors.

The study analyzed the chemical composition and hair growth-promoting properties of watercress oil (WCO) marketed in Saudi Arabia using GC-MS and in-silico methods. It identified 65.65% fatty acids, including oleic and palmitic acids, and confirmed the oil's safety with a pH of 5.53 and no toxic substances. Molecular docking showed that these fatty acids, except Docosanol, activated MAPK1, MAPK3, and MAPKp38 receptors, which are involved in hair growth regulation. The research supported the traditional use of warm oil application to enhance absorption and recommended further in-vitro studies to establish pharmacological mechanisms.

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