An Analysis of Gene Expression Data Involving Examination of Signaling Pathways Activation Reveals New Insights into the Mechanism of Action of Minoxidil Topical Foam in Men with Androgenetic Alopecia

June 2017 in “ Cell Cycle ”

Georgios N. Stamatas, Jeff Wu, Apostolos Pappas, Paradi Mirmirani, Thomas S. McCormick, Kevin D. Cooper, Mary C. Consolo, Jane Schastnaya, Ivan V. Ozerov, Alexander Aliper, Alex Zhavoronkov

minoxidil androgenetic alopecia gene expression signaling pathways keratin-associated proteins ILK Akt MAPK non-coding RNAs hair follicles Rogaine AGA MTF

TLDR Minoxidil foam helps hair growth by increasing good proteins and decreasing bad pathways in men with hair loss.

This document is a scientific paper from 5 years ago that analyzes the effects of minoxidil topical foam (MTF) on gene expression and activation of signaling pathways in men with androgenetic alopecia (AGA). The study found that both frontal and vertex scalp regions showed upregulation of genes that encode keratin-associated proteins and downregulation of ILK, Akt, and MAPK signaling pathways after MTF treatment. The study also identified dysregulated transcripts in the vertex and frontal scalp of responders after MTF treatment, including upregulation of keratin associated proteins and downregulation of various coding genes and non-coding RNAs. The study provides new insights into the molecular signatures of hair follicles in patients with AGA and their response to MTF treatment.

View this study on tandfonline.com →

Discuss this study in the Community →

Research cited in this study

19 / 19 results

Infundibular Protein and RNA Microarray Analyses from Affected and Clinically Non-Affected Scalp in Male Androgenetic Alopecia Patients

research Infundibular Protein and RNA Microarray Analyses from Affected and Clinically Non-Affected Scalp in Male Androgenetic Alopecia Patients

8 citations, March 2017 in “Experimental Dermatology”

Finasteride helps female-pattern hair loss.

research Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth

159 citations, October 2015 in “Science Advances”

Blocking JAK-STAT signaling can lead to hair growth.

research Androgenetic Alopecia: New Insights Into the Pathogenesis and Mechanism of Hair Loss

33 citations, August 2015 in “F1000Research”

New model shows muscle affects hair loss differently in men and women.

research mTOR Signaling Promotes Stem Cell Activation via Counterbalancing BMP-Mediated Suppression During Hair Regeneration

71 citations, January 2015 in “Journal of molecular cell biology/Journal of Molecular Cell Biology”

mTOR signaling helps activate hair stem cells by balancing out the suppression caused by BMP during hair growth.

Similar Response Patterns to Topical Minoxidil Foam 5% in Frontal and Vertex Scalp of Men with Androgenetic Alopecia: A Microarray Analysis

research Similar Response Patterns to Topical Minoxidil Foam 5% in Frontal and Vertex Scalp of Men with Androgenetic Alopecia: A Microarray Analysis

19 citations, September 2014 in “British Journal of Dermatology”

Minoxidil foam 5% effectively treats hair loss in both frontal and vertex scalp regions.

research Signaling Involved in Hair Follicle Morphogenesis and Development

223 citations, January 2014 in “International Journal of Molecular Sciences”

The conclusion is that proper signaling is crucial for hair growth and development, and errors can lead to cancer or hair loss.

research Microarray Analysis of Androgenetic and Senescent Alopecia: Comparison of Gene Expression Shows Two Distinct Profiles

27 citations, November 2013 in “Journal of Dermatological Science”

The conclusion is that androgenetic alopecia and senescent alopecia have unique gene changes, suggesting different causes and potential treatments for these hair loss types.

research Androgenetic Alopecia: Identification Of Four Genetic Risk Loci And Evidence For The Contribution Of WNT Signaling To Its Etiology

74 citations, June 2013 in “Journal of Investigative Dermatology”

Four genetic risk spots found for hair loss, with WNT signaling involved and a link to curly hair.

research Minoxidil Activates β-Catenin Pathway in Human Dermal Papilla Cells: A Possible Explanation for Its Anagen Prolongation Effect

88 citations, February 2011 in “Journal of Dermatological Science”

Minoxidil helps hair growth by activating the β-catenin pathway.

research Notch Signaling Regulates Late-Stage Epidermal Differentiation and Maintains Postnatal Hair Cycle Homeostasis

61 citations, January 2011 in “PloS one”

Notch signaling is essential for healthy skin and hair follicle maintenance.

research Human Hair Follicles Contain Two Forms of ATP-Sensitive Potassium Channels, Only One Sensitive to Minoxidil

102 citations, February 2008 in “The FASEB Journal”

One minoxidil-sensitive potassium channel exists in human hair follicles.

research Human Hair Growth Enhancement In Vitro By Green Tea Epigallocatechin-3-Gallate (EGCG)

108 citations, November 2006 in “Phytomedicine”

Green tea component EGCG could potentially promote human hair growth.

research Effect of Minoxidil on Proliferation and Apoptosis in Dermal Papilla Cells of Human Hair Follicle

149 citations, April 2004 in “Journal of Dermatological Science”

Minoxidil boosts hair growth by increasing cell production and survival.

research Androgenetic Alopecia: Pathogenesis and Potential for Therapy

174 citations, November 2002 in “Expert Reviews in Molecular Medicine”

Hair loss needs more research for better treatments.

research The Induction by Topical Minoxidil of Increased Fenestration in the Perifollicular Capillary Wall

12 citations, February 1999 in “British Journal of Dermatology”

Minoxidil increased small openings in blood vessel walls near growing hair in rats.

Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

research Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

416 citations, September 1997 in “Journal of Investigative Dermatology”

People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.

research The Use of Dermal Papilla Cells in Studies of Normal and Abnormal Hair Follicle Biology

19 citations, October 1996 in “Dermatologic Clinics”

Dermal papilla cells are key for hair growth and could help us understand and treat hair loss.

research Action of Topical Minoxidil in the Bald Stump-Tailed Macaque

78 citations, March 1987 in “Journal of The American Academy of Dermatology”

Minoxidil promotes hair growth but stops working when discontinued.

Minoxidil Stimulates Cutaneous Blood Flow in Human Balding Scalps: Pharmacodynamics Measured by Laser Doppler Velocimetry and Photopulse Plethysmography

research Minoxidil Stimulates Cutaneous Blood Flow in Human Balding Scalps: Pharmacodynamics Measured by Laser Doppler Velocimetry and Photopulse Plethysmography

137 citations, May 1984 in “Journal of Investigative Dermatology”

Minoxidil increases blood flow in balding scalps, possibly reversing hair loss.

Related Research

10 / 10 results

research A Survey of Patient Attitudes Towards Topical Minoxidil in the Treatment of Hair Loss

1 citations, October 2022 in “PubMed”

Patients generally have positive attitudes towards using topical Minoxidil for hair loss treatment.

research Sisaipho Alopecia Areata Treated With Tofacitinib and Oral Minoxidil

1 citations, August 2022 in “JAAD case reports”

Tofacitinib and oral minoxidil may help treat Sisaipho alopecia areata.

research Scalp Vascularization as a Marker of Topical Minoxidil Treatment Efficacy in Patients with Androgenetic Alopecia

March 2021 in “Postepy Dermatologii I Alergologii”

Minoxidil works equally well for hair growth regardless of scalp blood flow.

A Pilot Split-Scalp Study of Combined Fractional Radiofrequency Microneedling and 5% Topical Minoxidil in Treating Male Pattern Hair Loss

research A Pilot Split-Scalp Study of Combined Fractional Radiofrequency Microneedling and 5% Topical Minoxidil in Treating Male Pattern Hair Loss

25 citations, June 2018 in “Clinical and Experimental Dermatology”

Combined microneedling and minoxidil improves hair growth more than minoxidil alone.

An Analysis of Gene Expression Data Involving Examination of Signaling Pathways Activation Reveals New Insights into the Mechanism of Action of Minoxidil Topical Foam in Men with Androgenetic Alopecia

research An Analysis of Gene Expression Data Involving Examination of Signaling Pathways Activation Reveals New Insights into the Mechanism of Action of Minoxidil Topical Foam in Men with Androgenetic Alopecia

12 citations, June 2017 in “Cell Cycle”

Minoxidil foam helps hair growth by increasing good proteins and decreasing bad pathways in men with hair loss.

Treatment of Female Pattern Hair Loss with a Combination of Spironolactone and Minoxidil

An Analysis of Gene Expression Data Involving Examination of Signaling Pathways Activation Reveals New Insights into the Mechanism of Action of Minoxidil Topical Foam in Men with Androgenetic Alopecia

Research cited in this study

research Infundibular Protein and RNA Microarray Analyses from Affected and Clinically Non-Affected Scalp in Male Androgenetic Alopecia Patients

research Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth

research Androgenetic Alopecia: New Insights Into the Pathogenesis and Mechanism of Hair Loss

research mTOR Signaling Promotes Stem Cell Activation via Counterbalancing BMP-Mediated Suppression During Hair Regeneration

research Similar Response Patterns to Topical Minoxidil Foam 5% in Frontal and Vertex Scalp of Men with Androgenetic Alopecia: A Microarray Analysis

research Signaling Involved in Hair Follicle Morphogenesis and Development

research Microarray Analysis of Androgenetic and Senescent Alopecia: Comparison of Gene Expression Shows Two Distinct Profiles

research Androgenetic Alopecia: Identification Of Four Genetic Risk Loci And Evidence For The Contribution Of WNT Signaling To Its Etiology

research Minoxidil Activates β-Catenin Pathway in Human Dermal Papilla Cells: A Possible Explanation for Its Anagen Prolongation Effect

research Notch Signaling Regulates Late-Stage Epidermal Differentiation and Maintains Postnatal Hair Cycle Homeostasis

research Human Hair Follicles Contain Two Forms of ATP-Sensitive Potassium Channels, Only One Sensitive to Minoxidil

research Human Hair Growth Enhancement In Vitro By Green Tea Epigallocatechin-3-Gallate (EGCG)

research Effect of Minoxidil on Proliferation and Apoptosis in Dermal Papilla Cells of Human Hair Follicle

research Androgenetic Alopecia: Pathogenesis and Potential for Therapy

research The Induction by Topical Minoxidil of Increased Fenestration in the Perifollicular Capillary Wall

research Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

research The Use of Dermal Papilla Cells in Studies of Normal and Abnormal Hair Follicle Biology

research Action of Topical Minoxidil in the Bald Stump-Tailed Macaque

research Minoxidil Stimulates Cutaneous Blood Flow in Human Balding Scalps: Pharmacodynamics Measured by Laser Doppler Velocimetry and Photopulse Plethysmography

Related Community Posts Join

community The Real Cause Of Androgenetic Alopecia

community New and Interesting HairLoss Studies/Papers/Reviews

community Fats on your Head to Stop Hair Loss?

community New Treatments, and a Huge Group Buy with Lots of Research

community HLT Megathread on HMI-115 (key takeaways in comments)

community Maintaining hair until Breezula without Fin

Related Research

research A Survey of Patient Attitudes Towards Topical Minoxidil in the Treatment of Hair Loss

research Sisaipho Alopecia Areata Treated With Tofacitinib and Oral Minoxidil

research Scalp Vascularization as a Marker of Topical Minoxidil Treatment Efficacy in Patients with Androgenetic Alopecia

research A Pilot Split-Scalp Study of Combined Fractional Radiofrequency Microneedling and 5% Topical Minoxidil in Treating Male Pattern Hair Loss

research An Analysis of Gene Expression Data Involving Examination of Signaling Pathways Activation Reveals New Insights into the Mechanism of Action of Minoxidil Topical Foam in Men with Androgenetic Alopecia

research Treatment of Female Pattern Hair Loss with a Combination of Spironolactone and Minoxidil

research Effect of Minoxidil on Hair Growth in Androgenic Alopecia in Women

research Status of Scalp Hair and Therapy of Alopecia in Men in Switzerland

research Use of Topical Minoxidil Therapy for Androgenetic Alopecia in Women

research Topical Minoxidil (3%) in Extensive Alopecia Areata, Including Long-Term Efficacy