TLDR Dermal papilla cells are key for hair growth and could help us understand and treat hair loss.
The document from 1996 highlights the significance of dermal papilla cells in the regulation of hair growth and their potential role in hair disorders like alopecia areata and androgenetic alopecia. It acknowledges the complexity of hair follicle biology and the challenges in fully understanding and controlling hair disorders. The discovery of hair growth-stimulating drugs such as minoxidil and finasteride suggests that dormant follicles can be reactivated. The dermal papilla, crucial for hair growth, is smaller in balding follicles, and androgens may influence hair follicles through these cells. Cultured dermal papilla cells, despite being difficult to grow and maintain, have been shown to retain hair growth-promoting properties and can initiate hair follicle development when transplanted into animals. The document concludes that further research into the factors produced by these cells could provide deeper insights into both normal and abnormal hair follicle function.
30 citations,
March 1996 in “British Journal of Dermatology” 173 citations,
July 1995 in “Biochemical and biophysical research communications” Male hormones promote hair cell growth by using a growth factor from nearby skin cells.
157 citations,
April 1994 in “Clinical endocrinology” Androgens can cause hair growth in some areas and hair loss on the scalp.
34 citations,
July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” Human hair growth is influenced by androgen hormones, and red deer mane follicles have similar hormone receptors.
12 citations,
July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” Certain sex hormones and antiandrogens can either slow down or speed up the growth of human hair follicle cells depending on their concentration.
124 citations,
April 1992 in “Journal of Endocrinology/Journal of endocrinology” Beard hair follicles have more androgen receptors than non-balding scalp hair follicles.
68 citations,
December 1991 in “Annals of the New York Academy of Sciences” Hair growth can be induced by certain cells found at the base of hair follicles, and these cells may also influence hair development and regeneration.
5 citations,
February 2019 in “The New England Journal of Medicine” Certain mutations in the PADI3 gene may increase the risk of developing a type of scarring hair loss common in women of African descent.
21 citations,
October 2017 in “Journal of Investigative Dermatology” The document concludes that understanding dermal papilla cells is key to improving hair regeneration treatments.
19 citations,
October 1996 in “Dermatologic Clinics” Dermal papilla cells are key for hair growth and could help us understand and treat hair loss.
13 citations,
December 1983 in “Canadian journal of zoology” Heterotypic cell contacts likely help hair matrix cells differentiate during mouse hair follicle development.
