Hair Growth Promoting Activity of Cedrol Nanoemulsion in C57BL/6 Mice and Its Bioavailability

The study from March 23, 2021, examined the effects of Cedrol Nanoemulsion (CE-NE) on hair growth in C57BL/6 mice and its bioavailability. The CE-NE had an average particle size of 14.26 nm and showed a 36.7% release after 6 hours at pH 4.0. In vivo, CE-NE at a concentration of 50 mg/mL was more effective in promoting hair growth than both a control ointment and 2% minoxidil, with the CE-NE group displaying the heaviest hair weight (0.54 mg) and longest hair follicles (236.18 µm) after 21 days. Histological analysis revealed that hair follicles in the CE-NE group were predominantly in the anagen phase. Pharmacokinetic data indicated that CE-NE had a 4-fold higher area under the curve (AUC) and a 1.4-fold longer mean residence time (MRT) than the ointment, suggesting better bioavailability. The study involved 10 mice in each group for statistical analysis and concluded that CE-NE significantly promoted hair growth and could be a promising alternative to traditional treatments like minoxidil.