Preventive Effects of Cedrol Against Alopecia in Cyclophosphamide-Treated Mice

July 2016 in “ Environmental Toxicology and Pharmacology ”

Shanshan Chen, Yan Zhang, Qiu-Li Lu, Zhe Lin, Yuqing Zhao

cedrol Thuja orientalis oil chemotherapy-induced alopecia C57BL/6 mice minoxidil cyclophosphamide anagen hair follicles Rogaine CYP

Studysummary In this animal study, cedrol treatment reduced chemotherapy-induced alopecia in mice by preventing hair follicle damage, while minoxidil did not prevent alopecia under similar conditions. Our plain-language summary of this paper — not a Tressless recommendation.

The study, conducted 7 years ago, explored the effectiveness of cedrol, a component of Thuja orientalis oil, in preventing chemotherapy-induced alopecia (CIA) in 60 adult female C57BL/6 mice. The mice were pre-treated with cedrol or minoxidil before being exposed to cyclophosphamide (CYP) to induce hair loss. The findings indicated that cedrol at a dosage of 200 mg/kg resulted in only mild alopecia with a 40% reduction in hair loss, whereas mice treated with minoxidil experienced complete hair loss, similar to the untreated control group. Histological analysis showed that cedrol pre-treatment preserved 82.5% of anagen hair follicles from CYP damage, in contrast to only 37.0% in the control group. The study concluded that cedrol can effectively prevent hair follicle damage and promote hair regrowth after CIA, suggesting its potential as a treatment for managing hair loss due to chemotherapy. However, further research is needed to understand the mechanisms behind cedrol's protective effects.

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