Treatment and Prevention of Chemotherapy-Induced Alopecia with PTH-CBD, a Collagen-Targeted Parathyroid Hormone Analog, in a Non-Depilated Mouse Model

    September 2013 in “ Anti-Cancer Drugs ”
    Ranjitha Katikaneni, Tulasi Ponnapakkam, Osamu Matsushita … Robert C. Gensure
    Studysummary In this study, PTH-CBD effectively prevented and partially reversed chemotherapy-induced alopecia in mice, with pretreatment offering a better cosmetic outcome compared to therapeutic administration after hair loss onset.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on journals.lww.com →
    Discuss this study in the Community →

    Research cited in this study 10

    1. Tuning Wnt Signals for More or Fewer Hairs Journal of Investigative Dermatology · 2013
    2. Chemotherapy-Induced Alopecia: Emotional Distress and Mitigation Strategies Seminars in Cutaneous Medicine and Surgery · 2009
    3. Protection Against Chemotherapy-Induced Alopecia Pharmaceutical Research · 2006
    4. A Guide to Assessing Damage Response Pathways of the Hair Follicle: Lessons From Cyclophosphamide-Induced Alopecia in Mice Journal of Investigative Dermatology · 2005
    5. Effect of Adenovirus-Mediated Expression of Sonic Hedgehog Gene on Hair Regrowth in Mice With Chemotherapy-Induced Alopecia JNCI: Journal of the National Cancer Institute · 2001
    6. Topical Application of Cyclosporin A Induces Rapid Remodeling of Damaged Anagen Hair Follicles in Cyclophosphamide-Administered Mice Journal of Dermatological Science · 2001
    7. Permanent Alopecia Following Chemotherapy and Bone Marrow Transplantation Australasian Journal of Dermatology · 2000
    8. Reduction of Intrafollicular Apoptosis in Chemotherapy-Induced Alopecia by Topical Calcitriol Analogs ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1998
    9. Vitamin D3 and Chemotherapy-Induced Alopecia Nutrition · 1996
    10. Chemotherapy-Induced Alopecia Southern Medical Journal · 1993