Treatment and Prevention of Chemotherapy-Induced Alopecia with PTH-CBD, a Collagen-Targeted Parathyroid Hormone Analog, in a Non-Depilated Mouse Model

In a 2014 study, researchers explored the use of PTH-CBD, a collagen-targeted parathyroid hormone analog, to address chemotherapy-induced alopecia (CIA) in mice. The study demonstrated that PTH-CBD was effective in both preventing and treating CIA. Mice that received PTH-CBD prophylactically maintained their hair, while those treated after hair loss experienced partial regrowth. Histological analysis showed that PTH-CBD increased the number of normal hair follicles and reduced dystrophic changes. The study indicated that PTH-CBD could be a promising new therapy for CIA, with prophylactic use yielding better outcomes than treatment post hair loss. The number of mice used in the study was not mentioned in the summary. Existing treatments for CIA were noted to have limitations, and PTH-CBD was suggested to potentially overcome these issues without interfering with the efficacy of chemotherapy.