Design, Synthesis, and Biological Activity of TLR7-Based Compounds for Chemotherapy-Induced Alopecia

July 2019 in “ Investigational new drugs ”

Jincheng Yang, Kun Chen, Bin Wang, Liudi Wang, Shuya Qi, Weihua Wang

TLR7 TLR7 agonists TLR7 antagonists Imiquimod hair follicle stem cells hair cycle quinoline chemotherapy-induced alopecia

Studysummary TLR7-based compounds may help manage chemotherapy-induced hair loss.

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research Cancer Risk in Patients with Alopecia Areata: A Nationwide Population-Based Matched Cohort Study

15 citations , March 2018 in “Cancer Medicine”

This study found that alopecia areata patients had a slightly decreased overall cancer risk, with significantly lower risks for some cancers but higher risks for lymphoma, breast, kidney, and urinary bladder cancers.

research Pathogenesis and Treatment Options for Chemotherapy-Induced Alopecia: A Systematic Review

34 citations , January 2018 in “International Journal of Dermatology”

This review discusses chemotherapy-induced alopecia, highlighting its pathogenesis, clinical patterns, and current therapeutic approaches, with no new clinical results reported.

research Protective Mechanism of Adipose-Derived Stem Cells in Remodeling of the Skin Stem Cell Niche During Photoaging

13 citations , January 2018 in “Cellular Physiology and Biochemistry”

This study found that UVB irradiation alters skin stem cell niches leading to signs of photoaging, which may be reversed by adipose-derived stem cells through BMP4 pathway modulation and niche remodeling.

research Effects of Imiquimod on Hair Follicle Stem Cells and Hair Cycle Progression

25 citations , July 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that applying topical imiquimod during mid and late telogen in mice activates hair follicle stem cells and influences immune cell infiltration, promoting hair cycle entry independently of Wnt signaling.

research The Use of Scalp Cooling for Chemotherapy-Induced Hair Loss

13 citations , May 2016 in “British journal of nursing”

This article reviews recent research and advancements in scalp cooling for preventing chemotherapy-induced hair loss, reporting no new clinical results.

research Alopecia in General Medicine

13 citations , February 2016 in “Clinical Medicine”

This article discusses various types of alopecia relevant to hospital medicine and reports no new clinical findings, emphasizing the need for accurate diagnosis and understanding of associated psychological impacts.

research Isolation of Mouse Hair Follicle Bulge Stem Cells and Their Functional Analysis in a Reconstitution Assay

7 citations , January 2016 in “Methods in molecular biology”

This study describes the process of isolating and analyzing multipotent stem cells from mouse hair follicles for potential use in tissue engineering and regenerative medicine.

Treatment and Prevention of Chemotherapy-Induced Alopecia with PTH-CBD, a Collagen-Targeted Parathyroid Hormone Analog, in a Non-Depilated Mouse Model

research Treatment and Prevention of Chemotherapy-Induced Alopecia with PTH-CBD, a Collagen-Targeted Parathyroid Hormone Analog, in a Non-Depilated Mouse Model

20 citations , September 2013 in “Anti-Cancer Drugs”

In this study, PTH-CBD effectively prevented and partially reversed chemotherapy-induced alopecia in mice, with pretreatment offering a better cosmetic outcome compared to therapeutic administration after hair loss onset.

research Pathobiology of Chemotherapy-Induced Hair Loss

218 citations , January 2013 in “The Lancet Oncology”

This review discusses the pathobiology of chemotherapy-induced alopecia and highlights challenges in managing it, reporting no new clinical results and emphasizing the need for well-designed preclinical models to develop effective treatments.

research Chemotherapy-Induced Alopecia: Emotional Distress and Mitigation Strategies

155 citations , March 2009 in “Seminars in Cutaneous Medicine and Surgery”

This review covers various strategies to manage chemotherapy-induced alopecia, highlighting that agents like AS101 and minoxidil can reduce its severity but not prevent it, with no new clinical results reported.

research Protection Against Chemotherapy-Induced Alopecia

97 citations , September 2006 in “Pharmaceutical Research”

This review discusses advances in protecting against chemotherapy-induced alopecia and reports no new clinical results; calcitriol and cyclosporine A emerged as promising agents in animal models with broader efficacy across multiple chemotherapy drugs.

research The Biology of Hair Follicles

1113 citations , August 1999 in “The New England Journal of Medicine”

This article discusses the biologic and psychosocial significance of hair, the current limitations in hair growth drugs, and anticipates future therapies based on advancing hair follicle research.