Alopecia in General Medicine

February 2016 in “ Clinical Medicine ”

Rajani Nalluri, Matthew Harries

alopecia telogen effluvium chemotherapy-induced alopecia male pattern hair loss female pattern hair loss alopecia areata scarring alopecias minoxidil finasteride Janus kinase inhibitors frontal fibrosing alopecia infections systemic diseases pathobiology of hair loss Rogaine Propecia JAK inhibitors

From the encyclopedia

Alopecia Areata →

autoimmune disorder causing patchy hair loss

Minoxidil →

An essential vasodilator with some anti-androgenic effects

Finasteride →

Frontline, gold standard treatment for combatting androgenic alopecia

Studysummary This article discusses various types of alopecia relevant to hospital medicine and reports no new clinical findings, emphasizing the need for accurate diagnosis and understanding of associated psychological impacts.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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Research cited in this study

19 / 19 results

research Familial Aggregation of Alopecia Areata

295 citations , May 2016 in “Journal of the American Academy of Dermatology”

This review examines the immunological aspects of alopecia areata, focusing on genetic, neuroimmunological, and immune privilege factors, but does not report new clinical findings.

research Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition

701 citations , August 2014 in “Nature medicine”

This study found that JAK inhibitors promote hair regrowth in both mice and human alopecia areata cases by blocking key immune pathways involved in disease development.

research Efficacy of Interventions for Prevention of Chemotherapy-Induced Alopecia: A Systematic Review and Meta-Analysis

110 citations , August 2014 in “International journal of cancer”

This study found that scalp cooling significantly reduced the risk of chemotherapy-induced alopecia in breast cancer patients, while topical minoxidil and other interventions did not show significant efficacy.

research Killing Two Birds with One Stone: Oral Tofacitinib Reverses Alopecia Universalis in a Patient with Plaque Psoriasis

185 citations , June 2014 in “Journal of Investigative Dermatology”

This case report describes complete hair regrowth in a patient with alopecia universalis and improved psoriasis after treatment with the oral Janus kinase inhibitor, tofacitinib.

research Genes and Immune Response in Alopecia Areata: Review of the Alopecia Areata Research Summit First Day Proceedings

6 citations , December 2013 in “Journal of Investigative Dermatology Symposium Proceedings”

This review discusses recent advances in the understanding of alopecia areata, focusing on immunity and genetics, and presents potential targets for therapy without reporting new clinical results.

Analysis of Quantitative Changes in Hair Growth During Treatment With Chemotherapy or Tamoxifen in Patients With Breast Cancer: A Cohort Study

research Analysis of Quantitative Changes in Hair Growth During Treatment With Chemotherapy or Tamoxifen in Patients With Breast Cancer: A Cohort Study

24 citations , November 2013 in “British Journal of Dermatology”

This study found that chemotherapy in female breast cancer patients caused significant early hair loss, which began to recover three months after completion, whereas tamoxifen did not affect hair growth.

research Lichen Planopilaris Is Characterized By Immune Privilege Collapse Of The Hair Follicle's Epithelial Stem Cell Niche

220 citations , June 2013 in “The Journal of Pathology”

This study found that immune privilege collapse in the hair follicle bulge and associated immune responses may contribute significantly to the pathogenesis of lichen planopilaris, suggesting a potential autoimmune basis for the disease.

research Docetaxel and Permanent Alopecia

8 citations , April 2013 in “Journal of The American Academy of Dermatology”

This correspondence comments on the unknown prevalence of permanent alopecia following high-dose docetaxel chemotherapy and highlights the need for further understanding and prevention strategies.

research Recurrent Episodes of Hair Loss in a 37-Year-Old Woman

6 citations , October 2012 in “BMJ”

This case report describes a 37-year-old woman whose recurrent hair shedding was associated with low iron stores and a miscarriage, with improvements seen after increased iron intake.

research Hair Loss in Hospital Medicine: A Practical Guide

3 citations , July 2012 in “British journal of hospital medicine”

This article reviews common hair loss disorders, emphasizing their potential links to systemic disease and the importance of thorough diagnostic evaluation, but reports no new clinical results.

research British Association of Dermatologists’ Guidelines for the Management of Alopecia Areata 2012

218 citations , April 2012 in “British Journal of Dermatology”

This updated guideline from the British Association of Dermatologists discusses current recommendations for managing alopecia areata but reports no new clinical research findings.

research Hair Through the Female Life Cycle

40 citations , December 2011 in “British Journal of Dermatology”

This article reviews how chronological aging affects female scalp hair growth and suggests that multiple factors, including environmental influences, contribute to female pattern hair loss; no new clinical results are presented.

research Permanent Alopecia After Systemic Chemotherapy: A Clinicopathological Study of 10 Cases

57 citations , March 2011 in “The American Journal of Dermatopathology”

This study found that permanent alopecia can occur after certain chemotherapy treatments and presents as nonscarring hair loss similar to androgenetic alopecia, with specific histological features that could be misdiagnosed without proper clinicopathological correlation.

research S1 Guideline for Diagnostic Evaluation in Androgenetic Alopecia in Men, Women, and Adolescents

151 citations , August 2010 in “British Journal of Dermatology”

This guideline reviews the diagnosis of androgenetic alopecia and offers expert consensus recommendations tailored to males, females, and adolescents, but reports no new clinical results.

research Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity

717 citations , June 2010 in “Nature”

This study identified key genetic regions associated with alopecia areata, highlighting both acquired and innate immune involvement, with a novel link to the upregulation of ULBP ligands in autoimmune disease.

research Management of Primary Cicatricial Alopecias: Options for Treatment

98 citations , May 2008 in “British Journal of Dermatology”

This review discusses evidence-based guidance for managing primary cicatricial alopecias but reports no new clinical results, highlighting significant gaps in knowledge and the need for more quality trials.

research Women Who Present With Female Pattern Hair Loss Tend To Underestimate The Severity Of Their Hair Loss

29 citations , April 2004 in “British Journal of Dermatology”

This study found that women with female pattern hair loss awaiting treatment tend to underestimate their hair loss severity compared to their clinicians' evaluations.

research The Biology of Hair Follicles

1113 citations , August 1999 in “The New England Journal of Medicine”

This article discusses the biologic and psychosocial significance of hair, the current limitations in hair growth drugs, and anticipates future therapies based on advancing hair follicle research.

research A Randomized Trial of Minoxidil in Chemotherapy-Induced Alopecia

127 citations , July 1996 in “Journal of The American Academy of Dermatology”

This study found that in women undergoing chemotherapy after breast surgery, topical minoxidil significantly shortened the duration of hair loss compared to a placebo without significant side effects.