TLDR Chemotherapy can cause permanent, non-reversible hair loss similar to pattern baldness.
The study investigated permanent alopecia in 10 patients who had undergone systemic chemotherapy, revealing histological features similar to androgenetic alopecia. Patients had a reduced number of terminal hairs, an increased number of telogen and miniaturized vellus-like hairs, and a terminal to vellus hair ratio of 1:1, which is lower than normal. The anagen to telogen ratio was also lower than normal at 3.6:1. The study suggested that the cause of permanent alopecia could be due to a reduction in stem cell populations or a failure of hair matrix cells to reconnect with the dermal papilla post-chemotherapy. It highlighted that this type of alopecia is non-reversible and non-scarring, and can be misdiagnosed as androgenetic alopecia without proper clinicopathological correlation. The prevalence of chemotherapy-induced permanent alopecia is unclear, necessitating further research for understanding and prevention.
Cited in this study
8 / 8 results
67 citations
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August 2010 in “Journal of The American Academy of Dermatology” Some chemotherapy can cause permanent hair loss.
40 citations
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6 citations
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5 citations
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