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Glossary Hair Root Cells

specialized cells at the base of hair follicles

Hair root cells are specialized cells located at the base of the hair follicle, within the hair bulb. These cells are responsible for the production and growth of hair by dividing and differentiating to form the hair shaft and its surrounding structures. They play a crucial role in the hair growth cycle, including phases of growth (anagen), regression (catagen), and rest (telogen).

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Research

5 / 1000+ results

research Single-strand DNA breaks in human hair root cells exposed to mobile phone radiation

37 citations , March 2012 in “International Journal of Radiation Biology”

This study found that using a 900-MHz GSM mobile phone for 15 or 30 minutes significantly increased single-strand DNA breaks in human hair root cells near the phone.

MiR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells

research miR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells

18 citations , December 2020 in “Frontiers in cell and developmental biology”

This study found that extracellular vesicles from low-passage dermal papilla cells may activate hair growth by delivering miR-140-5p, which downregulates BMP2 signaling, suggesting potential therapeutic targets for alopecia.

Human Hair Outer Root Sheath Cells and Platelet-Lysis Exosomes Promote Hair Inductivity of Dermal Papilla Cells

research Human Hair Outer Root Sheath Cells and Platelet-Lysis Exosomes Promote Hair Inductivity of Dermal Papilla Cell

9 citations , June 2020 in “Tissue Engineering and Regenerative Medicine”

This study found that applying HHORSC exosomes may enhance the hair inductivity of dermal papilla cells, potentially improving treatments for hair loss.

research Interferon β Secreted from Human Hair Dermal Papilla Cells Inhibits the Growth of Outer Root Sheath Cells Cultured in Vitro

13 citations , January 2002 in “Biochemical and biophysical research communications”

This study observed that interferon β secreted by dermal papilla cells may negatively regulate the growth of outer root sheath cells in hair follicles.

research Outer root sheath cells secrete oxytocin for hair growth promotion and stem cell proliferation

March 2026 in “Journal of Bioscience and Bioengineering”

Oxytocin from hair cells helps hair growth and stem cell increase.

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Community Join

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community Cell senescence-targeted treatment for hair loss, has anyone tried any products/enzymes etc. that use this theory

5 upvotes 1 year ago

DHT causes hair loss by driving cells into senescence, and a polyphenol in black chokeberry may reverse this. A product using this theory is being considered for use alongside finasteride, minoxidil, and microneedling.

community Researchers working on ways to regenerate lost hair from stem cells identified a recipe for normal hair regeneration in the lab. “A method for cyclical regeneration of hair follicles from hair follicle stem cells and will help make hair follicle regeneration therapy a reality in the near future.”

263 upvotes 5 years ago

Hair loss treatments like finasteride, minoxidil, and hair transplants have side effects and limitations. There is hope for future advancements in stem cell therapy and hair follicle regeneration, though skepticism about their effectiveness and timeline persists.

community Is stem cell + PRP therapy legit?

13 upvotes 8 years ago

Stem cell and PRP therapy for hair loss is considered experimental and not consistently effective. Treatments like finasteride, minoxidil, and hair transplants are more established, but the potential for cloning chemically resistant hair follicles is seen as a promising future solution.

community New Hair Loss Cure: AMP-303 Is Back. It’s what PP405 should have been.

7 upvotes 5 months ago

AMP-303 and AMP-601 are new hair loss treatments targeting dermal papilla cells, with AMP-303 showing early efficacy in transitioning vellus hairs to terminal hairs after one injection. Further clinical trials are planned, and these treatments are seen as promising due to their biologic approach and less frequent application compared to daily treatments.

community Sanguisorba Officinalis Root Extract, and other FGF-5 inhibitors?

4 upvotes 9 years ago

The conversation discusses the potential of Sanguisorba Officinalis Root Extract as a treatment for hair loss by inhibiting FGF-5. The user also mentions the product évolis, which is based on this extract but is only available in the US and Australia.

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